Currently, the Centers for Disease Control reports close to 40,000 central line-associated bloodstream infections (CLABSI) occur in acute care facilities in the United States each year. Most are considered preventable. Evidence-based practices such as the CLABSI bundle and central line maintenance bundles have demonstrated their effectiveness in reducing CLABSI. This article reviews these best practices and provides a framework for consistent implementation.
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V-ATPase Disassembly at the Yeast Lysosome-Like Vacuole Is a Phenotypic Driver of Lysosome Dysfunction in Replicative Aging.
Aging Cell
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Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, New York, USA.
Declines in lysosomal acidification and function with aging are observed in organisms ranging from yeast to humans. V-ATPases play a central role in organelle acidification, and V-ATPase activity is regulated by reversible disassembly in many different settings. Using the yeast Saccharomyces cerevisiae as a replicative aging model, we demonstrate that V-ATPases disassemble into their V and V subcomplexes in aging cells, with release of V subunit C (Vma5) from the lysosome-like vacuole into the cytosol.
View Article and Find Full Text PDFThe rape and murder of a trainee doctor in RG Kar Medical College in Kolkata on August 9, 2024, was a brutal crime but had nothing to do with patients or violence by patients or their attendants against health workers. The accused is a civic volunteer who is said to have frequented the hospital as a tout, fleecing patients by promising to get them a bed or help them get tests done for free or at discounted rates [1]. However, following the incident, the protests by doctors, mostly resident doctors' associations across the country, zeroed in on protection for doctors and health workers from violence and attacks by patients through a central law as one of their main demands [2].
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Front Child Adolesc Psychiatry
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Mental Health Education and Counseling Center, Wudang Middle School Affiliated to Central China Normal University, Shiyan, China.
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