AI Article Synopsis
- The study aimed to investigate the link between the ADIPOQ rs2241766 gene SNP and breast cancer risk through a meta-analysis of existing literature.
- A systematic review of relevant articles found no significant association between the gene polymorphism and breast cancer risk, with pooled odds ratios indicating no strong correlation.
- The authors concluded that more extensive and rigorously designed studies are needed to validate these findings.
Article Abstract
Purpose: We aimed to conduct a meta-analysis to accurately evaluate the potential association between ADIPOQ rs2241766 gene SNP and breast cancer risk.
Methods: A systematic literature search on Cochrane Library, PubMed, Embase, Web of Science and China National Knowledge Infrastructure (CNKI) identified 8 articles with 1692 cases and 1890 controls. Strength of association was evaluated by pooled odds ratio (OR), 95 % confidence interval (CI) and p value. Funnel plots and Begger's regression test were applied for testing the publication bias. Statistical analysis of all data was performed by Stata 12.0.
Results: The meta-analysis results indicated that the ADIPOQ rs2241766 gene polymorphism did not significantly associated with the risk of breast cancer for these genetic models (TT vs. TG + GG: OR = 1.20, 95 % CI = 0.77-1.89, p=0.417; TT + TG vs. GG: OR = 1.05, 95 % CI = 0.71-1.56, p=0.805; T vs. G: OR =1.17, 95 % CI = 0.79-1.74, p=0.437).
Conclusions: This study indicated that no significant relationship between the ADIPOQ rs2241766 SNP and breast cancer. Further large-scale and well-designed studies will be indispensable to confirm our result.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572453 | PMC |
| http://dx.doi.org/10.1186/s41021-021-00221-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association of Gene Polymorphisms with Polycystic Ovary Syndrome: A Meta-analysis.
Gynecol Minim Invasive Ther
September 2024
Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India.
Objectives: Polycystic ovary syndrome (PCOS) is a prevalent endocrine-metabolic disorder affecting reproductive-aged women. Genetic factors play a significant role in its development. This meta-analysis assesses the associations between specific gene polymorphisms (Vitamin D receptor [VDR] and adiponectin [ADIPOQ]) and PCOS susceptibility.
View Article and Find Full Text PDFAssociation of Single Nucleotide Polymorphisms (SNPs) with Obesity Risk in Different Populations: A Systematic Review and Analysis.
Iran J Public Health
October 2024
National Center for Biotechnology, Astana, 010000, Kazakhstan.
Background: Thirty-two single nucleotide polymorphisms (SNPs) are commonly found in . APN levels are decreased in obesity, and SNPs of the gene affecting APN have varying associations with the development of obesity in different populations. This systematic review and meta-analysis aimed to investigate the association of SNPs in with the risk of obesity development in various populations.
View Article and Find Full Text PDFGenetic and Anthropometric Interplay: How Waist-to-Hip Ratio Modulates LDL-c Levels in Mexican Population.
Nutrients
October 2024
División de Estudios Sociales, Universidad Iberoamericana Ciudad de México, Mexico City 01219, Mexico.
Article Synopsis
- The study explored the relationship between specific genetic variations (SNPs) and obesity, involving 396 obese Mexican mestizo individuals and 142 individuals with normal weight.
- While most SNPs showed no significant link to obesity, the T allele of one SNP was associated with increased obesity risk.
- The research also found that genetic risk scores interact with waist-to-hip ratio, affecting LDL cholesterol levels, highlighting the importance of considering both genetics and body composition in addressing cardiovascular health.
Association of rs2241766 and rs1501299 polymorphisms in the adiponectin gene with metabolic syndrome.
Immun Inflamm Dis
September 2024
Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, Nanning, Guangxi, China.
Objective: To investigate the influence of adiponectin (APN) rs2241766 and rs1501299 polymorphisms on adiponectin levels and their association with metabolic syndrome (MetS).
Methods: Analyzed two polymorphisms (rs2241766 and rs1501299) of the adiponectin gene (ADIPOQ) in 210 MetS patients and 102 control patients using the polymerase chain reaction-restriction fragment length polymorphism method and DNA sequencing technology.
Results: The genotypes of the rs2241766 T/G and rs1501299 G/T polymorphism were significantly associated with serum APN levels in MetS patients.
The Association between ADIPOQ Gene Polymorphisms and Diabetic Retinopathy Risk: A Systematic Review and Meta-Analysis.
Medicina (Kaunas)
August 2024
Department of Ophthalmology, University General Hospital of Ioannina, 45500 Ioannina, Greece.
: Recent studies have focused on the association between the risk of diabetic retinopathy (DR) and the rs1501299 and rs2241766 polymorphisms of the ADIPOQ gene; however, their results remain inconclusive. Thus, a systematic review and meta-analysis were carried out to clarify the role of these polymorphisms in the development of DR. : A systematic search of electronic databases (PubMed, Scopus, and Cochrane Library) was conducted until 25 June 2024, and a reference list of relevant articles was collected, which explored the association between the rs1501299 and rs2241766 polymorphisms of the ADIPOQ gene and the risk of DR.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!