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Overexpression of l,d-Transpeptidase A Induces Dispensability of Rod Complex in .
ACS Infect Dis
November 2024
Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247 667, India.
Antimicrobial resistance (AMR) is a significant global threat, and the presence of resistance-determinant genes is one of the major driving forces behind it. The bacterial rod complex is an essential set of proteins that is crucial for cell survival due to its role in cell wall biogenesis and shape maintenance. Therefore, these proteins offer excellent potential as drug targets; however, compensatory mutations in nontarget genes render this complex nonessential.
View Article and Find Full Text PDFActivity of mecillinam against USA urinary tract clinical isolates from 2017 to 2020 including isolates resistant to comparator antibiotics.
J Glob Antimicrob Resist
December 2024
Maxel Consulting ApS, Jyllinge, Denmark.
Article Synopsis
- A study was conducted to investigate the effectiveness of mecillinam and pivmecillinam against urinary tract infection (UTI) bacteria in the U.S. from 2017 to 2020, highlighting its potential as a treatment option.
- Mecillinam showed high susceptibility rates (94.9%) among UTI-causing Enterobacterales, especially against extended-spectrum beta-lactamase (ESBL)-positive strains (98.2%).
- The findings support the clinical development of mecillinam as a promising first-line therapy for uncomplicated UTIs, especially when other common antibiotics showed higher resistance rates.
Evaluation of several routine methods for fosfomycin and mecillinam susceptibility testing of Enterobacterales urine isolates.
J Antimicrob Chemother
October 2024
Laboratoire de Bactériologie-Hygiène, CHU de Toulouse, Université de Toulouse Paul Sabatier, Toulouse, France.
Objectives: Performance evaluation of routine laboratory methods to determine the susceptibility of Enterobacterales urinary isolates to fosfomycin (oral administration) and mecillinam.
Methods: We collected 347 Enterobacterales isolates from monomicrobial midstream urine samples from women with significant bacteriuria and leukocyturia. Mostly non-Escherichia coli isolates (i.
Review of the In Vitro Microbiological Activity of Mecillinam Against Common Uropathogens in Uncomplicated Urinary Tract Infection: Focus on Resistant Pathogens.
Open Forum Infect Dis
June 2024
Department of Clinical Microbiology, Central Hospital, Växjö, Sweden.
Antimicrobial resistance in uropathogens commonly causing urinary tract infections (UTIs) is a growing problem internationally. Pivmecillinam, the oral prodrug of mecillinam, has been used for over 40 years, primarily in Northern Europe and Canada. It is recommended in several countries as a first-line agent for the treatment of uncomplicated UTIs (uUTIs) and is now approved in the United States.
View Article and Find Full Text PDFInteractions of plumbagin with five common antibiotics against Staphylococcus aureus in vitro.
PLoS One
January 2024
College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Staphylococcus aureus is the main culprit, causing a variety of severe clinical infections. At the same time, clinics are also facing the severe situation of antibiotic resistance. Therefore, effective strategies to address this problem may include expanding the antimicrobial spectrum by exploring alternative sources of drugs or delaying the development of antibiotic resistance through combination therapy so that existing antibiotics can continue to be used.
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