Donor Unrestricted T Cells: Linking innate and adaptive immunity.

Vaccine

Division of Pulmonary & Critical Care Medicine, Department of Medicine, Portland VA Medical Center, Oregon Health & Science University, United States. Electronic address:

Published: December 2021

Donor Unrestricted T Cells (DURTs) are characterized by their use of antigen presentation molecules that are often invariant. As these cells recognize diverse mycobacterial antigens, often found in BCG, these cells have the potential to either serve as targets for vaccination, or as a means to enable the induction of traditional T and B cell immunity. Here, we will review specific DURT family members, and their relationship to BCG.

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Source
http://dx.doi.org/10.1016/j.vaccine.2021.10.044DOI Listing

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