Endovascular plaque composition is strongly related to stent strut stress and is responsible for strut fatigue, stent failure, and possible in-stent restenosis. To evaluate the effect of plaque on artery wall resistance to expansion we performed in silico analysis of atherosclerotic vessels. We generated finite element models from in vivo intravascular ultrasound virtual histology images to determine local artery surface stiffness and determined which plaque structures have the greatest influence. We validated the predictive capacity of our modeling approach by testing an atherosclerotic peripheral artery ex vivo with pressure-inflation testing at physiological pressures ranging from 10 to 200 mmHg. For this purpose, the in silico deformation of the arterial wall was compared to that observed ex vivo. We found that calcification had a positive effect on surface stiffness with fibrous plaque and necrotic core having negative effects. Additionally, larger plaque structures demonstrated significantly higher average surface stiffness and calcification located nearer the lumen was also shown to increase surface stiffness. Therefore, more developed plaques will have greater resistance to expansion and higher stent strut stress, with calcification located near the lumen further increasing stress in localized areas. Thus, it may be expected that such plaque structures may increase the likelihood of localized stent strut fracture.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665142 | PMC |
| http://dx.doi.org/10.1016/j.jmbbm.2021.104927 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Application of nanoparticles with activating STING pathway function in tumor synergistic therapy.
Int Immunopharmacol
January 2025
Department of Chemoradiotherapy, Ningbo NO.2 Hospital, Ningbo, Zhejiang, 315000, China. Electronic address:
Although immunotherapy is currently one of the most promising methods for cancer treatment, its clinical application is limited due to issues such as excessive autoimmune responses and lack of specificity. Therefore, there is a need to improve immunotherapy by integrating emerging medical technologies with traditional treatments. The activation of the cGAS-STING pathway plays a crucial role in innate immunity and antiviral defense, making it highly promising for immunotherapy and attracting significant attention.
View Article and Find Full Text PDFA compliant metastructure design with reconfigurability up to six degrees of freedom.
Nat Commun
January 2025
Morphing Matter Lab, Human-Computer Interaction Institute, Carnegie Mellon University, Pittsburgh, PA, USA.
Compliant mechanisms with reconfigurable degrees of freedom are gaining attention in the development of kinesthetic haptic devices, robotic systems, and mechanical metamaterials. However, available devices exhibit limited programmability and form-customizability, restricting their versatility. To address this gap, we propose a metastructure concept featuring reconfigurable motional freedom and tunable stiffness, adaptable to various form factors and applications.
View Article and Find Full Text PDFKinematics, kinetics, and muscle activations during human locomotion over compliant terrains.
Sci Data
January 2025
University of Delaware, Department of Mechanical Engineering, Newark, DE, 19716, USA.
Walking on compliant terrains, like carpets, grass, and soil, presents a unique challenge, especially for individuals with mobility impairments. In contrast to rigid-ground walking, compliant surfaces alter movement dynamics and increase the risk of falls. Understanding and modeling gait control across such soft and deformable surfaces is thus crucial for maintaining daily mobility.
View Article and Find Full Text PDFDevelopment of chitosan-based films with invertase enzyme for active packaging: Physicochemical parameters, structure, application, and storage.
Int J Biol Macromol
January 2025
Department of Food Science, Federal University of Lavras (UFLA), Lavras 37200-000, Brazil.
The use of active packaging made from biodegradable polymers can contribute to the environment and to the food industry by increasing the shelf life of their products. This study aimed to produce chitosan-based films incorporated with the invertase enzyme (1, 2, 5, 9, and 10 %) as an alternative to avoid sucrose crystallization in the confectionery industry. The optimum activity of the invertase enzyme was observed at 55 °C and pH 5, thus, the films made with the film-forming solution adjusted to pH 5 and dried at 55 °C were compared with those without pH adjustment and dried at room temperature.
View Article and Find Full Text PDFPhysicochemical Properties of Curen® Filaments Versus Nylon Filaments in Toothbrush Bristles: An In Vitro Study.
Cureus
December 2024
Medical Affairs, Dr. Reddy's Laboratories Ltd., Hyderabad, IND.
Background Toothbrush manufacturers commonly use bristle materials such as nylon, polybutylene terephthalate, polypropylene, polyethylene terephthalate, boar hair, bamboo, carbon fiber, silicone, polylactic acid, or their modifications such as Curen. Nylon filaments have long been demonstrated to be durable and are widely used, but not much is known regarding the performance of Curen filaments compared to nylon filaments. This in vitro study compared the stiffness, abrasion potential, abrasion resistance, and bristle surface changes of Curen and nylon filaments.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!