The founding of the journal by the American Chemical Society 60 years ago was a highlight of the Society's growing commitment to chemically driven biochemistry. It was a commitment that was nearly an additional 60 years in the making. In that time, biological chemistry was becoming more molecularly focused. Its relationship to the traditional chemical disciplines became apparent to a generation of young chemists, who grappled with defining the field's core chemical principles and creating new areas of research for a new journal. The path to was exciting, but it was also complex and difficult. Even its naming was arguable.
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Influence of vitamin D supplementation on muscle strength and exercise capacity in Mongolian schoolchildren: secondary outcomes from a randomised controlled trial.
BMJ Open Sport Exerc Med
September 2024
Blizard Institute, Queen Mary University of London, London, UK.
Article Synopsis
- - The study aimed to see if weekly oral vitamin D supplementation affects grip strength, explosive leg power, cardiorespiratory fitness, or lung volumes in Mongolian schoolchildren aged 6-13.
- - Conducted as a 3-year randomized, placebo-controlled trial with over 8,000 participants, the results showed a significant increase in vitamin D levels in those receiving supplementation but no improvement in physical fitness measures or lung function.
- - Ultimately, while vitamin D supplementation raised serum levels in children with low baseline levels, it did not impact the targeted health outcomes, indicating a need for further research on vitamin D effects in this population.
Vitamin D for the management of chronic obstructive pulmonary disease.
Cochrane Database Syst Rev
September 2024
Centre for Applied Respiratory Research Innovation and Implementation, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.
Background: COPD is a common, preventable and treatable airway disease, and is currently the third leading cause of death worldwide. About one billion people worldwide are estimated to have vitamin D deficiency or insufficiency. Vitamin D deficiency is common among people with COPD, and has been reported to be associated with reduced lung function and increased risk of acute exacerbations of COPD.
View Article and Find Full Text PDFInfluence of vitamin D supplementation on muscle strength and exercise capacity in Mongolian schoolchildren: a randomised controlled trial.
medRxiv
March 2024
Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.
Objective: To determine whether weekly oral vitamin D supplementation influences grip strength, explosive leg power, cardiorespiratory fitness or spirometric lung volumes in Mongolian schoolchildren.
Methods: Multicentre, randomised, double-blind, placebo-controlled clinical trial conducted in children aged 6-13 years at baseline attending 18 schools in Ulaanbaatar. The intervention was weekly oral doses of 14,000 IU vitamin D (n=4418) or placebo (n=4433) for 3 years.
Asterics: a simple tool for the ExploRation and Integration of omiCS data.
BMC Bioinformatics
October 2023
Université de Toulouse, INRAE, UR MIAT, 31326, Castanet-Tolosan, France.
Background: The rapid development of omics acquisition techniques has induced the production of a large volume of heterogeneous and multi-level omics datasets, which require specific and sometimes complex analyses to obtain relevant biological information. Here, we present ASTERICS (version 2.5), a publicly available web interface for the analyses of omics datasets.
View Article and Find Full Text PDFVitamin D for the management of asthma.
Cochrane Database Syst Rev
February 2023
Asthma UK Centre for Applied Research, Wolfson Institute of Population Health, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.
Background: Since the previous Cochrane Review on this topic in 2016, debate has continued surrounding a potential role for vitamin D in reducing risk of asthma exacerbation and improving asthma control. We therefore conducted an updated meta-analysis to include data from new trials completed since this date.
Objectives: To evaluate the effectiveness and safety of administration of vitamin D or its hydroxylated metabolites in reducing the risk of severe asthma exacerbations (defined as those requiring treatment with systemic corticosteroids) and improving asthma symptom control.
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