Purpose The purpose of this study was to assess postoperative partial knee replacement (PKR) functional improvement using the postoperative Oxford Knee Score for Activity and Participation Questionnaire (OKS-APQ). PKR includes medial, lateral, and patellofemoral knee arthroplasty. Methods A search of a National Health Service hospital database was made to identify eligible candidates for a survey of Patient-Reported Outcome Measure (PROM). Database records were collected for patients who had medial, lateral, and patellofemoral knee arthroplasty. The first author, an orthopaedic surgery resident, retrospectively reviewed the data and selected 318 patient records for inclusion in a questionnaire survey. The inclusion criteria were: patients who had PKR within three years from the time of the study and patients who don't have medical problems that may affect their mobility; for example, balance problems. The survey used the postoperative Oxford Knee Score for Activity and Participation Questionnaire (OKS-APQ), Tegner Activity Score (TAS), and four questions were added to the present study, namely, three free-text questions and one visual analogue score (VAS). The survey was sent by post seeking the patients' responses. Results Two-hundred five responded to the survey out of 318; a 64% response rate. The ceiling and floor effects were determined from patients' answers. Survey questions included: What is the most demanding activity you routinely do every month on your new knee? The patients' answers were divided into four groups. First, 29% were limited to low functional demand activities, for example, light walking for less than a mile. Second, 43% were involved in domestic work and sports activities, for example, golf, skittles, bowling, squatting, swimming, and gardening. Third, 21% had progressed to higher demand activities, for instance, dancing, racquet sports, cycling, and yoga. Fourth, 7% were performing higher demand activities involving impacts, for example, skiing, heavy gym workout, and marathon running. Conclusion The postoperative questionnaire demonstrated activities ranging from high-impact activities, for example, skiing, and from higher demand activities, for example, dancing to low function activities, for example, light walking.
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http://dx.doi.org/10.7759/cureus.18439 | DOI Listing |
BMC Oral Health
January 2025
Department of Restorative Dentistry, Periodontology and Endodontology, University Medicine Greifswald, Greifswald, Germany.
Background: Despite considerable improvements in oral health in recent decades, caries and periodontitis are still widespread, ranking among the most prevalent diseases worldwide and requiring future research. The German National Cohort (NAKO Gesundheitsstudie, NAKO) is a large-scaled, multidisciplinary, nationwide, multi-centre, population-based, prospective cohort study with oral examinations that aims to provide a resource to study risk factors for major diseases. The aim of the present article is to provide the methodological background, to report on the data quality, and to present initial results of the oral examinations.
View Article and Find Full Text PDFNat Chem Biol
January 2025
Clayton Foundation Peptide Biology Laboratories, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Fatty acid esters of hydroxy fatty acids (FAHFAs) are bioactive lipids that are positively correlated with metabolic health in humans and mice. Since their discovery, understanding the role and regulation of FAHFAs has been a prime focus of research into these lipids. In this Review, we describe how FAHFAs are quantitatively measured from biological samples.
View Article and Find Full Text PDFAcc Chem Res
January 2025
Organisch-Chemisches Institut, Universität Münster, Corrensstrasse 40, 48149 Münster, Germany.
ConspectusSkeletal editing, which involves adding, deleting, or substituting single or multiple atoms within ring systems, has emerged as a transformative approach in modern synthetic chemistry. This innovative strategy addresses the ever-present demand for developing new drugs and advanced materials by enabling precise modifications of molecular frameworks without disrupting essential functional complexities. Ideally performed at late stages of synthesis, skeletal editing minimizes the need for the cost- and labor-intensive processes often associated with synthesis, thus accelerating the discovery and optimization of complex molecular architectures.
View Article and Find Full Text PDFJMIR Form Res
January 2025
CIRCLE - Complex Intervention Research in Health and Care, Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Background: Parents of children treated for cancer may experience psychological difficulties including depression, anxiety, and posttraumatic stress. Digital interventions, such as internet-administered cognitive behavioral therapy, offer an accessible and flexible means to support parents. However, engagement with and adherence to digital interventions remain a significant challenge, potentially limiting efficacy.
View Article and Find Full Text PDFPharmaceut Med
January 2025
Pharmaceutical Medicine, Dover Heights, Sydney, NSW, Australia.
Pharmaceutical medicine professionals have to face many ethical problems during the entire life span of new medicines extending from animal studies to broad clinical practice. The primary aim of the general ethical principles governing research conducted in humans is to diminish the physical and psychological burdens of the participants in human drug studies but overlooks many additional social and ethical problems faced by medicine developers. These arise mainly at the interface connecting the profit-oriented pharmaceutical industry and the healthcare-centered medical profession cooperating in medicines development.
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