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Bridging the gap between non-canonical and canonical Wnt signaling through Vangl2. | LitMetric

Bridging the gap between non-canonical and canonical Wnt signaling through Vangl2.

Semin Cell Dev Biol

Department of Molecular and Cellular Biology, University of Guelph, 50 Stone Rd. E, Guelph, ON, Canada N1G 2W1. Electronic address:

Published: May 2022

AI Article Synopsis

  • * Wnt5a plays a key role in inhibiting Wnt/β-catenin signaling by mobilizing calcium in cancer cells, while also activating Vangl2 for polarity and migration, though calcium’s role in this developmental process is less clear.
  • * Despite the potential for interaction between canonical and non-canonical Wnt pathways, in vivo evidence of their cross talk is limited, raising questions about how cells differentiate between the two signaling types when they do occur simultaneously.

Article Abstract

Non-canonical Wnt signaling (encompassing Wnt/PCP and WntCa) has a dual identity in the literature. One stream of research investigates its role in antagonizing canonical Wnt/β-catenin signaling in cancer, typically through Ca, while the other stream investigates its effect on polarity in development, typically through Vangl2. Rarely do these topics intersect or overlap. What has become clear is that Wnt5a can mobilize intracellular calcium stores to inhibit Wnt/β-catenin in cancer cells but there is no evidence that Vangl2 is involved in this process. Conversely, Wnt5a can independently activate Vangl2 to affect polarity and migration but the role of calcium in this process is also limited. Further, Vangl2 has also been implicated in inhibiting Wnt/β-catenin signaling in development. The consensus is that a cell can differentiate between canonical and non-canonical Wnt signaling when presented with a choice, always choosing non-canonical at the expense of canonical Wnt signaling. However, these are rare events in vivo. Given the shared resources between non-canonical and canonical Wnt signaling it is perplexing that there is not more in vivo evidence for cross talk between these two pathways. In this review we discuss the intersection of non-canonical Wnt, with a focus on Wnt/PCP, and Wnt/β-catenin signaling in an attempt to shed some light on pathways that rarely meet at a crossroads in vivo.

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Source
http://dx.doi.org/10.1016/j.semcdb.2021.10.004DOI Listing

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