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Incident thrombocytopenia and bleeding risk in elderly patients with atrial fibrillation on direct oral anticoagulants: insights from the ATHEROsclerosis in Atrial Fibrillation study.
Res Pract Thromb Haemost
October 2024
Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Background: The bleeding risk of patients with atrial fibrillation (AF) changes over time. Most studies thus far evaluated only the baseline bleeding risk with discordant results. The impact of incident thrombocytopenia during direct oral anticoagulant (DOAC) therapy and its relation to bleeding has not been previously investigated.
View Article and Find Full Text PDFThe Labiomandibular Fold Anatomy for Comprehensive Lower Facial Rejuvenation: A Micro-Computed Tomography Investigation.
Aesthetic Plast Surg
January 2025
Department of Plastic and Reconstructive Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No.1, Shuaifuyuan, Dongcheng District, Beijing, China.
Background: Perioral rejuvenation is challenging due to the lack of spatial anatomical understanding of the labiomandibular fold (LMF). The LMF's formation mechanism remains underexplored due to intricate relationships between musculature and subcutaneous structures. This study aimed to clarify the three-dimensional structures of the LMF using micro-computed tomography and histology.
View Article and Find Full Text PDFDeciphering Polymer Interactions in Bioconjugates with Different Architectures by Structural Analysis via Time-Resolved Limited Proteolysis Mass Spectrometry.
Angew Chem Int Ed Engl
January 2025
Universität Würzburg, Institute for Pharmacy and Food Chemistry, Am Hubland, 97074, Würzburg, Germany.
Therapeutic proteins are commonly conjugated with polymers to modulate their pharmacokinetics but often lack a description of the polymer-protein interaction. We deployed limited proteolysis mass spectrometry (LiP-MS) to reveal the interaction of polyethylene glycol (PEG) and PEG alternative polymers with interferon-α2a (IFN). Target conjugates were digested with the specific protease trypsin and a "heavy" N-IFN wild type (IFN-WT) for time-resolved quantification of the cleavage dynamics.
View Article and Find Full Text PDFEstimating Palatal and Pharyngeal Muscle Contraction in Hindi Syllable Pronunciation using Computational Modeling.
Indian J Plast Surg
December 2024
Department of Radiodiagnosis, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Article Synopsis
- Speech functions impacted by cleft palate involve complex sound production from various organs, and while traditional evaluations post-surgery are subjective, this study aims to provide objective assessments by measuring muscle contractions during speech.
- A healthy volunteer underwent dynamic MRI while pronouncing Hindi syllables, allowing researchers to create 3D models of the palate and pharynx, then analyze muscle contractions using a finite element model for different sounds.
- Results showed varying contraction levels for the palate and pharyngeal wall with different syllables, with the highest contractions for the syllable /k/ and the potential to use this data to quantify speech issues and evaluate surgical effectiveness in larger populations.
Animacy processing by distributed and interconnected networks in the temporal cortex of monkeys.
Front Behav Neurosci
December 2024
Department of Neurophysiology, Niigata University School of Medicine, Niigata, Japan.
Animacy perception, the ability to discern living from non-living entities, is crucial for survival and social interaction, as it includes recognizing abstract concepts such as movement, purpose, and intentions. This process involves interpreting cues that may suggest the intentions or actions of others. It engages the temporal cortex (TC), particularly the superior temporal sulcus (STS) and the adjacent region of the inferior temporal cortex (ITC), as well as the dorsomedial prefrontal cortex (dmPFC).
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