Skin Testing With Peach Peel Extract IgE to Pru p 3 as a Stronger Predictor of Peach-Induced Anaphylaxis.

The most important peach fruit allergen is Pru p 3, followed by Pru p 1, Pru p 4, and Pru p 7. We aimed to assess their role in subjects with peach fruit-induced allergy (anaphylaxis and OAS) and compare skin prick tests (SPT) vs. specific immunoglobulin E (sIgE) for predicting anaphylaxis. We also selected a control group. SPT included prevalent inhalant and plant food allergens plus peach peel extract. The sIgE to Pru p 1, Pru p 3, Pru p 4, and Pru p 7 were quantified. Compared with controls (n = 42), cases (n = 41) were younger ( = 0.003), more frequently female ( < 0.05) and had higher SPT positivity to peach peel (44% vs. 2.4%, < 0.0001). There were significant differences in sensitization to several pollens: , , , (all < 0.001); and fruits: apple ( < 0.04), peanut ( < 0.002), tomato ( < 0.005), and melon ( < 0.05). Pru p 3 sIgE was detected in 61% of all cases (85% anaphylaxis and 38% OAS; < 0.01 each) and 5% of controls ( < 0.001). Pru p 4 sIgE was present in 19% of cases and 7% of controls. The sIgE to Pru p 1 and Pru p 7 were not found. The odds ratio to predict anaphylaxis for peach peel SPT was 113 (confidence interval [CI], 20-613; < 0.0001); for sIgE to Pru p 3, 22 (CI, 5.3-93; < 0.0001); and for SPT positivity to selected plant food allergens, 5 (CI, 1-19; < 0.05). In our study group, SPT with peel peach extract was a better predictor of anaphylaxis than Pru p 3 sIgE or other variables considered. The role of sIgE to Pru p 1, Pru p 4, and Pru p 7 seemed negligible.