Spread of the delta coronavirus variant: Africa must be on watch.

Public Health Pract (Oxf)

Faculty of Pharmaceutical Sciences, University of Ilorin, Kwara State, Nigeria.

Published: November 2021

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553652PMC
http://dx.doi.org/10.1016/j.puhip.2021.100209DOI Listing

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Article Synopsis
  • SARS-CoV-2 can infect liver cells (hepatocytes), leading to elevated liver enzymes and more severe disease in those with pre-existing liver conditions.
  • The study shows that the virus replicates and spreads in hepatocytes, with infection being dependent on two specific proteins, ACE2 and TMPRSS2, which are found on the liver cells.
  • Infection causes rapid liver cell death, with the Omicron variant causing quicker but less extensive damage compared to other strains, as seen in both human liver cells and infected mice.
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