Background: Although rectal prolapse is not a life-threatening condition, it can cause defecation disorders, anal incontinence, sensory abnormalities, and other problems that can seriously affect quality of life.
Aim: To study the efficacy of the modified Gant procedure for elderly women with internal rectal prolapse.
Methods: Sixty-three elderly female patients with internal rectal prolapse underwent the modified Gant procedure. The preoperative and postoperative anal symptoms, Patient Assessment of Constipation Quality of Life (PAC-QOL), Wexner incontinence score, incontinence quality of life score, and complications (massive hemorrhage, infection, anorectal stenosis, and anorectal fistula) were compared.
Results: The improvement rates of postoperative symptoms were defecation disorders (84.5%), anal distention (69.6%), defecation sensation (81.4%), frequent defecation (88.7%), and anal incontinence (42.9%) ( < 0.05). All dimensions and total scores of the PAC-QOL after the procedure were lower than those before the operation ( < 0.05). The postoperative anal incontinence score and Wexner score were significantly lower than those before the procedure ( < 0.05). The quality of life and total scores of postoperative anal incontinence were significantly higher than those before the procedure ( < 0.05). There were no serious complications and no deaths.
Conclusion: The modified Gant procedure has significant advantages in the treatment of elderly women with internal rectal prolapse.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546830 | PMC |
http://dx.doi.org/10.12998/wjcc.v9.i29.8702 | DOI Listing |
Cancers (Basel)
April 2024
Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.
High-grade serous ovarian cancer (HGSOC) is the predominant subtype of ovarian cancer (OC), occurring in more than 80% of patients diagnosed with this malignancy. Histological and genetic analysis have confirmed the secretory epithelial of the fallopian tube (FT) as a major site of origin of HGSOC. Although there have been significant strides in our understanding of this disease, early stage detection and diagnosis are still rare.
View Article and Find Full Text PDFInt J Biol Macromol
April 2023
School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, PR China. Electronic address:
Herein, a novel superdispersed calcium borate@polydopamine/cellulose acetate-laurate nanocomposite (CTAB-CB@PDA/CAL) is successfully synthesized by a double-template-regulated biomimetic mineralization strategy using PDA/CAL as a hard template and cetyltrimethylammonium bromide (CTAB) as a soft template and surface hydrophobic modifier. The results show that CB can grow uniformly on the CAL surface, and CTAB can improve the hydrophobicity of CTAB-CB@PDA/CAL due to the synergistic effect of the double templates, which contributes to the enhanced dispersibility and long-term dispersion stability of CTAB-CB@PDA/CAL in poly-alpha-olefin (PAO) base oil. Furthermore, CB can rapidly enter the friction interface due to the long substituents of CTAB and CAL, so CTAB-CB@PDA/CAL used as a lubricant additive in PAO base oil exhibits superior tribological performance compared to CB, CB/CAL, and CB@PDA/CAL.
View Article and Find Full Text PDFMult Scler Relat Disord
February 2023
Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address:
Background: In relapsing-remitting multiple sclerosis (RRMS), smoking is a known risk factor for disease susceptibility and disability progression. However, its impact on the efficacy of oral disease-modifying drugs (DMDs) is unclear. Therefore, we initiated a single-center, retrospective, observational study to investigate the relationship between smoking and disease activity in RRMS patients under oral DMDs.
View Article and Find Full Text PDFWorld J Clin Cases
October 2021
Department of Anorectal, Central Hospital Affiliated to Shandong First Medical University, Jinan 250013, Shandong Province, China.
Background: Although rectal prolapse is not a life-threatening condition, it can cause defecation disorders, anal incontinence, sensory abnormalities, and other problems that can seriously affect quality of life.
Aim: To study the efficacy of the modified Gant procedure for elderly women with internal rectal prolapse.
Methods: Sixty-three elderly female patients with internal rectal prolapse underwent the modified Gant procedure.
ACS Appl Mater Interfaces
August 2021
Department of Vascular Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
The sonic hedgehog (SHH) signaling pathway exhibits aberrant activation in triple-negative breast cancer (TNBC), wherein it regulates several malignant phenotypes related to tumor metastasis. GANT61, an inhibitor of the SHH signaling pathway, may offer promise when administered in combination with conventional chemotherapy to treat metastatic TNBC. However, poor bioavailability and substantial off-target toxicity limit its clinical application.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!