Vancomycin-resistant enterococci (VRE) are emerging as an important multidrug-resistant pathogen causing nosocomial infections, predominantly bacteremia and urinary tract infections. VRE bacteremia has caused a significant increase in the duration of the hospital stay and mortality and had caused high public health threat due to limited treatment options. Between October 2017 and September 2020, all consecutive patients with culture-proven bloodstream infection with species, isolated for the first time, were included in the study. A total of 427 species were identified, and antimicrobial susceptibility tests were performed and interpreted using Clinical and Laboratory Standard Institute guidelines. Of the total 427 species isolated, 63 (45.6%) were VRE. Among them, 51/63 (81%) were () and 5/63 (8%) were . There was an increased trend of VRE rate in the bloodstream infections of 6.12% (2018), 13.2% (2019), and 19.2% (2020). The majority of the VRE patients [43/63 (68%)] were admitted to the intensive care units (ICUs). Vancomycin A (VanA) is the most common phenotype isolated from 51/63(81%) patients. This increasing trend of VRE bacteremia is a red alert to the clinicians and the infection control practitioners, so that strict antibiotic policies and proper adherence to the infection control practices can be initiated to reduce the VRE rate. Sivaradjy M, Gunalan A, Priyadarshi K, Madigubba H, Rajshekar D, Sastry AS. Increasing Trend of Vancomycin-resistant Enterococci Bacteremia in a Tertiary Care Hospital of South India: A Three-year Prospective Study. Indian J Crit Care Med 2021;25(8):881-885.
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http://dx.doi.org/10.5005/jp-journals-10071-23916 | DOI Listing |
JAMA Surg
December 2024
Division of Vascular Surgery and Endovascular Therapy, Johns Hopkins University, Baltimore, Maryland.
Importance: Fenestrated and branched endovascular aortic repairs (F/BEVAR) have been adopted by many centers. However, national trends of F/BEVAR use remain unclear, particularly at sites who perform them without an US Food and Drug Adminstration (FDA)-approved investigational device exemption (IDE).
Objective: To quantify the use of F/BEVAR in the US and to determine if mortality was different at IDE vs non-IDE sites.
ChemSusChem
December 2024
ICPEES: Institut de Chimie et Procedes pour l'Energie l'Environnement et la Sante, catalysis and materials, FRANCE.
The increasing availability of electrical energy generated from clean, low-carbon, renewable sources like solar and wind power is paving the way for a more sustainable future. This has resulted in a growing trend in the chemical industry to increase the share of electricity use in chemical processes, particularly catalytic ones. Replacing fossil fuels with electricity can significantly reduce the carbon footprint associated with chemical production.
View Article and Find Full Text PDFChemSusChem
December 2024
Tula State University, BioChemTech Research Center, Pr. Lenina 92, 300012, Tula, RUSSIAN FEDERATION.
The burgeoning field of materials science is currently witnessing a paradigm shift toward the utilization of renewable plant biomass as a viable chemical source for the production of sustainable materials. This trend is substantiated by a significant corpus of recent experimental and theoretical research focused on the synthesis and property analysis of such polymers. Within this context, polybenzoxazines stand out as a pioneering class of thermosetting polymers, distinguished by their exceptional thermal and mechanical characteristics, coupled with the feasibility of synthesizing their precursor monomers from eco-friendly, renewable resources, including plant phenols and furfurylamine.
View Article and Find Full Text PDFChemistry
December 2024
University of Münster Department of Chemistry and Pharmacy: Westfalische Wilhelms-Universitat Munster Fachbereich 12 Chemie und Pharmazie, Institut für Anorganische und Analytische Chemie, Corrensstr. 28/30, 48149, Münster, GERMANY.
Two artificial imidazole-derived nucleobases, HQIm (3H-imidazo[4,5-f]quinolin-5-ol) and CaIm (imidazole-4-carboxylate), were introduced into short DNA duplexes to systematically investigate their thermal stability upon metal ion coordination. Metal-mediated base pairs are formed with the 3d metal ions CoII, NiII and ZnII, as well as with the lanthanoid ions EuIII and SmIII, which induce a thermal stabilization of up to 8 °C upon binding. The latter are the first lanthanoid-mediated base pairs involving only four donor atoms that result in a significant duplex stabilization.
View Article and Find Full Text PDFGraefes Arch Clin Exp Ophthalmol
December 2024
Department of Ophthalmology and Laboratory of Eye Research, Rabin Medical Center - Beilinson Hospital, Felsenstein Medical Research Center, 39 Jabotinski St., Petach Tikva, 49100, Israel.
Background: Diabetes poses a risk to diabetic keratopathy in up to two-thirds of patients. Insulin-degrading enzyme (IDE) is a protease that can break down insulin and several growth factors and may impair wound healing. Increased IDE levels have been found in fluid from diabetic skin ulcers.
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