AI Article Synopsis
- Diabetes mellitus is a significant public health issue marked by chronic high blood sugar levels, with strategies focusing on inhibiting α-glucosidase and reducing inflammation for treatment.
- Researchers investigated essential oils from three Clausena plant species in Thailand for their potential as natural functional foods to help treat diabetes and its complications.
- The essential oils, particularly from C. excavata and C. harmandiana, demonstrated strong antioxidant and anti-inflammatory properties, indicating their potential use in developing diabetes treatments.
Article Abstract
Diabetes mellitus constitutes one of the most important public health problems. It is defined as a metabolic disorder characterized by a chronic hyperglycemic condition. The inhibition of α-glucosidase and inflammation effects is still considered a strategy for the treatment of diabetes. The aim of this study was to search for new and effective natural functional foods agents for the complementary treatment of diabetes and other related complications. The essential oils from the leaves of three Clausena plants collected in Thailand: C. harmandiana, C. guillauminii and C. excavata were obtained by hydrodistillation. The chemical compositions, antioxidant, anti-α-glucosidase and anti-inflammatory activities of these essential oils were evaluated. The C. excavata and C. harmandiana essential oils contained seselin and terpinen-4-ol, respectively, as the major components and showed strong inhibition of DPPH free radical, α-glucosidase, lipoxygenase and nitric oxide activities with the IC values ranging from 0.031±0.005 to 0.702±0.003 mg/mL. From these results, it may be concluded that seselin and terpinen-4-ol are important for high antioxidant, anti-α-glucosidase, and anti-inflammatory activities. Therefore, these Clausena essential oils may be useful in industrial applications for the treatment of diabetes and other related complications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.5650/jos.ess19294 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Serum pharmacochemistry of Panacis Japonici Rhizoma extract based on UPLC-Q-Exactive Orbitrap-MS].
Zhongguo Zhong Yao Za Zhi
December 2024
Thirdgrade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University Yichang 443002, China College of Medicine and Health Sciences, China Three Gorges University Yichang 443002, China.
In this study, the chemical components of Panacis Japonici Rhizoma extract and absorbed components in rats were identified by ultra-high performance liquid chromatography-quadrupole exactive orbitrap mass spectrometry(UPLC-Q-Exactive Orbitrap-MS). The separation was performed by gradient elution on Waters UPLC BEH C_(18) column(2.1 mm×100 mm, 1.
View Article and Find Full Text PDFFatty acid composition, total phenolic and total flavonoid contents, and antioxidant activity of Niger seed (Guizotia abyssinica) accessions collected from major producer areas of Ethiopia.
PLoS One
January 2025
Department of Chemistry, College of Natural and Computational Science, Debre Tabor University, Debre Tabor, Ethiopia.
Background: Oils from various sources are vital nutritional components with a variety of roles in our body. Niger seed (Guzoita abyssinica) is endemic to Ethiopia and is among the major oil seed crops grown in the country. The fatty acid composition and the concentration of other bioactive phytochemicals in it vary with species type, geographical origin, cultivation season, and varietal types.
View Article and Find Full Text PDFPharmacokinetics of Geraniol and Its Metabolites in Mice After Oral Administration.
Food Sci Nutr
January 2025
Aging Stress Response Research Project Team, National Center for Geriatrics and Gerontology Obu-city Aichi Japan.
Geraniol is an acyclic monoterpene alcohol that is extracted from the essential oils of aromatic plants. Geraniol has several biological activities such as anti-cancer, anti-inflammatory, antioxidant, and neuroprotective effects. However, the pharmacokinetics of geraniol and its metabolites after oral administration remain unknown in mice.
View Article and Find Full Text PDFEssential oil blend and monensin for feedlot steers consuming backgrounding and finishing diets: growth performance, methane emissions using the GreenFeed system, and feeding behavior.
Transl Anim Sci
January 2025
Lethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, Alberta T1J 4B1, Canada.
A study was conducted to assess growth performance, methane (CH) emissions, and feeding behavior of feedlot steers consuming backgrounding and finishing diets with an essential oil blend (EO), monensin (Mon), and their combination (EO + Mon). The study was structured as a 2 × 2 factorial, with two feed additive treatments (Control, EO) and two monensin treatments (no Monensin, Monensin). One hundred Angus × steers were evenly distributed across each treatment into four pens, and each dietary phase consisted of four, 28-d periods.
View Article and Find Full Text PDFExploring the Effects of Ionic Liquid on the Toughness of Palm Leaf Manuscripts.
Langmuir
January 2025
State Key Laboratory of Solidification Processing, School of Materials Science and Engineering, Northwestern Polytechnical University, Xi'an 710072, China.
Palm leaf manuscripts, crafted from specially treated palm leaves, are invaluable historical documents. However, they degrade and tend to become brittle over time. To date, plant essential oils and glycerin are the used materials to improve the flexibility of palm leaf manuscripts, but the effective duration of these materials is short due to their volatility.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!