Telmisartan Exerts Cytotoxicity in Scirrhous Gastric Cancer Cells by Inducing G/G Cell Cycle Arrest.

Background/aim: This study aimed to assess the effects of telmisartan (TEL), a potential antitumor agent, and its mechanism of action in the regulation of apoptosis, autophagy, and cell cycle in scirrhous gastric cancer (SGC).

Materials And Methods: The effect of TEL on the viability and chromatin condensation of OCUM-2M and OCUM-12 cells was assessed. Protein expression and the cell cycle were analysed using western blotting and flow cytometry, respectively.

Results: TEL inhibited cell proliferation in a dose-dependent manner and increased chromatin condensation and autophagy marker LC3-II levels in OCUM-12 cells. TEL also increased the proportion of cells in the G/G phase transition.

Conclusion: Apoptosis and autophagy are partially involved in the inhibitory effect of TEL on cell proliferation. Additionally, TEL caused G/G cell cycle arrest. Therefore, TEL could be a promising treatment for SGC.