Background: Previous bench-top studies examined the details of the mechanical environment of rigidly fixed occluding teeth. It was demonstrated that during each chomp, contacting molar teeth experience in-occlusal-plane forces (F ) that are highly transient in magnitude and direction.
Objectives: The objectives of this study are to identify F behaviours that are attributable to the presence of a visco-elastic periodontal ligament (PDL) analogue, and to assess the necessity of incorporating it into future studies.
Methods: A weighted maxillary molar denture tooth was lowered onto, and raised from, a matching mandibular molar 10 times. The latter was supported by a load cell that continuously measured F . For statistical purposes, the test was repeated with 21 (n = 21) different occlusal relationships obtained with 0.05 mm incremental shifts of the lower assembly.
Results: Overall, the results are similar to those of rigid attachment but the details of the F profiles are very different.
Conclusion: The PDL plays a major role in the mechanical environment of occlusion, suggesting that, in general (not necessarily always), it should be integrated into studies of occlusion.
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http://dx.doi.org/10.1111/joor.13278 | DOI Listing |
Immunopharmacol Immunotoxicol
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Department of Regenerative Dental Medicine, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Tokushima, Japan.
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Department of Growth and Development, University of Nebraska Medical Center, 4000 East Campus Loop South, 68583-0740, Lincoln, NE, US.
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Department of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing 100081, China.
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December 2024
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China. Electronic address:
Introduction: The periodontal ligament (PDL), a dynamic connective tissue that anchors teeth to the alveolar bone, enables tooth retention and facilitates continuous turnover. The integrity of the periodontium is maintained by periodontal ligament stem cells (PDLSCs), whose dysfunction and senescence with age can disrupt tissue homeostasis, hinder injury repair, and lead to tooth loss, ultimately impacting overall health. Transforming growth factor-β1 (TGF-β1) is known for its regenerative properties and as a functional paracrine factor in stem cell therapy, but its precise role in modulating PDLSC activity remains controversial and poorly understood.
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Department of Periodontics and Oral Mucosal Diseases, The Affiliated Stomatological Hospital of Southwest Medical University, Luzhou 646000, Sichuan, China; Luzhou Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, Southwest Medical University, Luzhou 646000, Sichuan, China. Electronic address:
Oxidative stress (OS) inhibits the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs). Equol (Eq), a phytoestrogen, exhibits notable antioxidant properties and potential for preventing osteoporosis. However, the research on the regulatory effects of Eq on stem cell osteogenesis remains limited.
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