AI Article Synopsis
- There is a continual demand for new antiviral agents with unique structures and effective results.
- Natural products, like crocin-1 and crocin-2, have been isolated and shown to outperform ribavirin in combating the tobacco mosaic virus (TMV).
- A series of crocetin diester derivatives were synthesized, with some compounds demonstrating even greater antiviral activity than the original crocins and ribavirin, positioning them as promising new candidates for antiviral treatment.
Article Abstract
The development of antiviral agents with an original structure and noticeable effect is always in great need. Natural products are important lead compounds in the development of new pesticides. Crocin-1 and crocin-2 were effectively isolated from and found to have higher anti-tobacco mosaic virus (TMV) activity levels than ribavirin. A series of the crocetin diester derivatives were synthesized with separated crocetin-1 as material and evaluated for their anti-TMV activities. They could be dissolved in common organic solvents as dichloromethane, ethyl acetate, tetrahydrofuran, and methanol. Compounds , , , , and displayed higher activities than ribavirin. Compound with significantly higher antiviral activities than lead compounds (crocin-1 and crocin-2) emerged as a new antiviral candidate.
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| http://dx.doi.org/10.1021/acs.jafc.1c03884 | DOI Listing |
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