As academia and industry push the boundaries of chemical biology more and more from basic science into impacting human health, we asked experts in the field what uniquely positions chemical biology as a translational science, how and when to maximize its potential, and where the field is headed. We also reflect personally on how chemical biology has impacted our careers in industry and academia.
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| http://dx.doi.org/10.1002/cbic.202100536 | DOI Listing |
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Revealing Toxicological Mechanisms of Small Molecules Using Chemical Biology.
Chem Res Toxicol
January 2025
Department of Chemistry, University of California, Riverside, California 92521, United States.
Defining the underlying toxicological mechanisms of various small molecules is of utmost importance in understanding the pathogenesis of chemical exposure-related human diseases and developing safe and effective therapeutics. Herein, we discuss the toxicological mechanisms of different small molecules utilizing the different tools of chemical biology.
View Article and Find Full Text PDFNeuroprotective Indole Alkaloids from the Soil-Derived Fungus sp. XZ8.
J Nat Prod
January 2025
Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China.
A chemical investigation of the soil-derived fungus sp. XZ8 led to the isolation of five new indole alkaloids, trichindoles A-E (-), with diverse architectures, along with seven known analogues (-). Their structures were elucidated by extensive spectroscopic data analysis, and their absolute configurations were determined by single-crystal X-ray diffraction and modified Mosher's method.
View Article and Find Full Text PDFRational Design of Dual-Targeted Nanomedicines for Enhanced Vascular Permeability in Low-Permeability Tumors.
ACS Nano
January 2025
School of Medicine, Nankai University, Tianjin 300071, China.
Designing dual-targeted nanomedicines to enhance tumor delivery efficacy is a complex challenge, largely due to the barrier posed by blood vessels during systemic delivery. Effective transport across endothelial cells is, therefore, a critical topic of study. Herein, we present a synthetic biology-based approach to engineer dual-targeted ferritin nanocages (Dt-FTn) for understanding receptor-mediated transport across tumor endothelial cells.
View Article and Find Full Text PDFCascade-Responsive Nanoparticles for Efficient CRISPR/Cas9-Based Glioblastoma Gene Therapy.
ACS Appl Mater Interfaces
January 2025
Key Laboratory of Functional Polymer Materials of Ministry of Education, College of Chemistry, Nankai University, Tianjin 300071, China.
CRISPR/Cas9 (CRISPR, clustered regularly interspaced short palindromic repeats) gene editing technology represents great promise for treating glioblastoma (GBM) due to its potential to permanently eliminate tumor pathogenic genes. Unfortunately, delivering CRISPR to the GBM in a safe and effective manner is challenging. Herein, a glycosylated and cascade-responsive nanoparticle (GCNP) that can effectively cross the blood-brain barrier (BBB) and activate CRISPR/Cas9-based gene editing only in the GBM is designed.
View Article and Find Full Text PDFPalladium Nanosheet Enables Synergistic Electrocatalytic Dehalogenation via Direct and Indirect Electron Transfer Mechanisms.
ACS Appl Mater Interfaces
January 2025
Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, College of Environmental Science and Engineering, Hunan University, Changsha 410082, China.
Electrocatalytic dehalogenation is a promising method for the remediation of chlorinated organic pollutants. The dehalogenation performance is controlled by catalytic activity, and the underlying electrocatalytic dehalogenation mechanisms need to be carefully investigated for guiding the design of catalyst. Here we report the preparation of a new Pd-based catalyst with a nanosheet structure (Pd NS) by a simple wet-chemical reduction method.
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