AI Article Synopsis
- Breast cancer is a prevalent cancer among women, and genetic variations are studied to understand their impact on the risk of developing the disease.
- The study focused on a population in northeastern Iran, comparing 476 breast cancer patients with 524 healthy controls using a specific genotyping method.
- Findings indicate that a particular genotype significantly increases breast cancer risk, suggesting it may be an important genetic factor contributing to susceptibility in this population.
Article Abstract
Breast cancer (BC) is one of the most common cancers among women. The influence of genetic variations on BC risk has been thus far assessed via genome-wide association studies. has been recognized as a major player in BC progression. In this study, the association between and BC was evaluated in a population from northeastern Iran. This study was conducted on 476 patients with BC and 524 healthy controls. The genotyping method used was an amplification-refractory mutation system. The genotype conferred a statistically significant increased risk in patients in comparison with controls. Additionally, in the recessive model, versus was statistically significant (OR = 0.34; 95% CI: 0.12-0.96; p = 0.042). This study found that , as a susceptibility genetic factor, may affect BC risk in the Iranian population.
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| http://dx.doi.org/10.2217/fon-2021-0197 | DOI Listing |
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