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| http://dx.doi.org/10.4103/aian.AIAN_860_20 | DOI Listing |
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Evaluating the Antimalarial Potential of D-α-Tocopherol Polyethylene Glycol 1000 Succinate and α-Tocopherol, In Vivo Studies in Plasmodium berghei-Infected Mice and Molecular Docking Insights.
Chem Biodivers
December 2024
UFPA: Universidade Federal do Para, Biological Science, Rua Augusto Corrêa S/N, Guamá, Belém 66075-900, Pará, Brazil, Belem, BRAZIL.
Oxidative stress is a pivotal factor in the pathogenesis of malaria, contributing to the development of conditions such as anemia, respiratory complications, and cerebral malaria. To counteract oxidative damage, we evaluated the effects of vitamin E (α-TOH) and D-α-tocopherol polyethylene glycol succinate 1000 (TPGS) supplementation on parasitemia progression, mortality rate, and blood-brain barrier (BBB) permeability in Plasmodium berghei ANKA-infected mice. The mice were divided into four groups: a control group (untreated and uninfected), an infected group (Pb), a TPGS+Pb group, and an α-TOH+Pb group.
View Article and Find Full Text PDFAnti-septin complex positive autoimmune encephalitis after severe falciparum malaria: a case report.
Malar J
December 2024
Department of Infectious Diseases and Tropical Medicine, Hospital St. Georg, Leipzig, Germany.
Background: Post malaria neurologic syndrome (PMNS) is a rare complication of malaria, usually caused by Plasmodium falciparum. The clinical picture is highly variable and ranges from qualitative disturbances of consciousness and psychosis to damage to the peripheral nerves, usually occurring three to eight weeks after treated malaria.
Case Presentation: We report the case of a 54-year-old male who presented with recurrent clinical symptoms three and a half weeks after severe falciparum malaria.
Plasmodium knowlesi Infection Is Associated With Elevated Circulating Biomarkers of Brain Injury and Endothelial Activation.
J Infect Dis
December 2024
Department of Infection Biology, London School of Hygiene and Tropical Medicine, United Kingdom.
Background: Malaria remains a major public health concern with substantial morbidity and mortality worldwide. In Malaysia, the emergence of Plasmodium knowlesi has led to a surge in zoonotic malaria cases and deaths in recent years. Signs of cerebral involvement have been observed in a noncomatose, fatal case of knowlesi infection, but the potential impact of this malaria species on the brain remains unexplored.
View Article and Find Full Text PDFPost-mortem diagnosis of malaria in decomposed and embalmed body.
Forensic Sci Med Pathol
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Chair and Department of Forensic Medicine, Jagiellonian University Medical College, Kraków, Poland.
The diagnosis of malaria during the autopsy of a decomposed corpse may prove challenging. Macroscopic changes are non-specific and may include, among others, cerebral oedema, pulmonary oedema, hepatosplenomegaly and, on occasion, the presence of petechiae. The most effective diagnostic tools for malaria are the examination of blood smears and the use of rapid immunochromatographic tests.
View Article and Find Full Text PDFSevere falciparum malaria in young children is associated with an increased risk of post-discharge hospitalization: a prospective cohort study.
Malar J
December 2024
Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indiana, USA.
Article Synopsis
- A study conducted in Uganda followed children aged 6 months to 4 years who were discharged from the hospital after being treated for specific severe malaria manifestations, comparing their post-discharge health to asymptomatic community children.
- Over 12 months, 56.6% of children with severe malaria experienced one or more hospitalizations, significantly higher than the 30.8% of community children, with a majority of the hospitalizations being malaria-related.
- The findings indicate a pressing need for research into post-discharge malaria prevention treatments to help reduce the healthcare burden on children who have suffered from severe malaria.
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