AI Article Synopsis
- Vitamin D supplementation has been linked to reductions in total cholesterol, LDL cholesterol, and triglycerides in clinical trials, but does not affect HDL cholesterol levels.
- A real-world cohort study analyzed over 18,000 individuals to determine the relationship between changes in vitamin D levels and shifts in lipid profiles over a year, revealing that increased vitamin D correlates with lower levels of TC, LDL-C, and TG.
- The study showed significant differences in lipid level changes between those who increased and decreased vitamin D levels, while changes in vitamin D were not associated with HDL cholesterol levels, even after controlling for various health factors.
Article Abstract
In clinical trials, vitamin D supplementation has been reported to reduce serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) but not high-density lipoprotein cholesterol (HDL-C). In this cohort study we evaluated the association between changes in vitamin D (25-hydroxyvitamin D) and changes in lipid levels in a real-world setting. Changes in lipid levels over a 1-year period were evaluated among individuals whose vitamin D levels increased (group 1) or decreased (group 2) by ≥ 10 ng/mL in year 2018 versus 2017 (cohort 1; n = 5580), in 2019 versus 2018 (cohort 2, n = 6057), or in 2020 versus 2019 (cohort 3, n = 7249). In each cohort, levels of TC, LDL-C, and TG decreased in group 1 and increased in group 2. Between-group differences in average changes in the 3 cohorts ranged from 10.71 to 12.02 mg/dL for TC, from 7.42 to 8.95 mg/dL for LDL-C, and from 21.59 to 28.09 mg/dL for TG. These differences were significant after adjusting for age, sex, race, education, body mass index, blood pressure, smoking status, geographical location, and baseline levels of vitamin D and lipids (P < 0.001). Changes in vitamin D levels were not significantly associated with changes in HDL-C levels.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563916 | PMC |
| http://dx.doi.org/10.1038/s41598-021-01064-1 | DOI Listing |
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