A new antimicrobial nor-friedelane-type triterpenoid and other constituents from Hook. f. (Lamiaceae).

Chemical investigation of the ethanol extract from the whole plant of led to the isolation of a new nor-triterpenoid () along with seventeen known compounds () including seven triterpenoids, nine flavonoids and one steroid. Their structures were established on the basis of 1D- and 2D-NMR, IR, and MS experiments, and by comparison of their spectroscopic data with those of similar compounds reported in the literature. The EtOH extract and some isolated triterpenoids (- and were subjected to antimicrobial assays against a panel of pathogenic microorganisms, including Gram-positive and Gram-negative bacteria, and fungi using broth microdilution method. The EtOH extract displayed moderate activity (MIC = 512 µg/mL) against MSSA1, SDINT and H99. Compounds , and showed the most potent antimicrobial effect with MICs of 32-256 µg/mL.