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Ocular examinations before and after total ear canal ablation and bulla osteotomy can help recognize and prevent potential vision-threatening abnormalities in cats and dogs.
J Am Vet Med Assoc
January 2025
2College of Veterinary Medicine, The Ohio State University, Columbus, OH.
Objective: To report ocular examination findings before and after total ear canal ablation and lateral bulla osteotomy (TECALBO) and ventral bulla osteotomy (VBO) in cats and dogs.
Methods: At The Ohio State University and MedVet Columbus, ophthalmic examinations were performed on client-owned animals for which a TECALBO or VBO was indicated. Examination findings and postoperative complications relating to ophthalmic and/or neuro-ophthalmic diseases were recorded prior to surgery (T0) and at 1 day (T1), 2 to 3 weeks (T14), and ± 2 months (T60) postoperatively.
Pupil sparing oculomotor nerve palsy with concomitant Horner syndrome as a presentation of mantle cell lymphoma relapse.
BMJ Case Rep
December 2024
Radiology Department, Queen Alexandra Hospital, Portsmouth, Hampshire, UK.
A woman in her 70s, with a background of mantle cell lymphoma (MCL), presented with headache and diplopia. Neuro-ophthalmic examination revealed a combination of Horner syndrome and ipsilateral pupil sparing oculomotor nerve palsy (ONP). Cerebrospinal fluid immunophenotyping demonstrated CD5 positive clonal B lymphocytes, consistent with neurological involvement by MCL.
View Article and Find Full Text PDFOcular Immune-Related Adverse Events Associated with PD-1 Inhibitors: From Molecular Mechanisms to Clinical Management.
Semin Ophthalmol
November 2024
Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Article Synopsis
- This text emphasizes the need for ophthalmologists and oncologists to better understand ocular immune-related adverse events (irAEs) caused by PD-1 inhibitors for early detection and management.
- A review of 70 case reports found that melanoma and lung cancer were the most common malignancies associated with these adverse events, primarily involving the PD-1 inhibitors pembrolizumab and nivolumab.
- The most frequent ocular complications included uveitis and myasthenia gravis, typically managed with steroids, while severe cases may necessitate stopping the PD-1 inhibitors, highlighting the importance of collaboration between specialties for effective patient care.
Emerging Ocular Side Effects of Immune Checkpoint Inhibitors: A Comprehensive Review.
Biomedicines
November 2024
Department of Surgery, Division of Ophthalmology, University of Sherbrooke, Sherbrooke, QC J1G 2E8, Canada.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, offering significant improvements in patient survival across various malignancies. However, their use is associated with a broad spectrum of immune-related adverse events (irAEs), including those affecting the eye and its surrounding structures, collectively termed ocular irAEs (OirAEs). Although rare, OirAEs (e.
View Article and Find Full Text PDFNon-invasive assessment of intracranial pressure through the eyes: current developments, limitations, and future directions.
Front Neurol
October 2024
Vision Science Group (Orthoptics), Faculty of Health, UTS, Sydney, NSW, Australia.
Detecting and monitoring elevated intracranial pressure (ICP) is crucial in managing various neurologic and neuro-ophthalmic conditions, where early detection is essential to prevent complications such as seizures and stroke. Although traditional methods such as lumbar puncture, intraparenchymal and intraventricular cannulation, and external ventricular drainage are effective, they are invasive and carry risks of infection and brain hemorrhage. This has prompted the development of non-invasive techniques.
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