Purpose: Prostate-specific membrane antigen (PSMA)-targeted PET is increasingly used for staging prostate cancer (PCa) with high accuracy to detect significant PCa (sigPCa). [ Ga]PSMA-11 PET/MRI-guided biopsy showed promising results but also persisting limitation of sampling error, due to impaired image fusion. We aimed to assess the possibility of intraoperative quantification of [F]PSMA-1007 PET/CT uptake in core biopsies as an instant confirmation for accurate lesion sampling.
Methods: In this IRB-approved, prospective, proof-of-concept study, we included five consecutive patients with suspected PCa. All underwent [F]PSMA-1007 PET/CT scans followed by immediate PET/CT-guided and saturation template biopsy (3.1 ± 0.3 h after PET). The activity in biopsy cores was measured as counts per minute (cpm) in a gamma spectrometer. Pearson's test was used to correlate counts with histopathology (WHO/ISUP), tumor length, and membranous PSMA expression on immunohistochemistry (IHC).
Results: In 43 of 113 needles, PCa was present. The mean cpm was overall significantly higher in needles with PCa (263 ± 396 cpm) compared to needles without PCa (73 ± 44 cpm, p < 0.001). In one patient with moderate PSMA uptake (SUV 8.7), 13 out of 24 needles had increased counts (100-200 cpm) but only signs of inflammation and PSMA expression in benign glands on IHC. Excluding this case, ROC analysis resulted in an AUC of 0.81, with an optimal cut-off to confirm PCa at 75 cpm (sens/spec of 65.1%/87%). In all 4 patients with PCa, the first or second PSMA PET-guided needle was positive for sigPCa with high counts (156-2079 cpm).
Conclusions: [F]PSMA-1007 uptake in PCa can be used to confirm accurate lesion sampling of the dominant tumor intraoperatively. This technique could improve confidence in imaging-based biopsy guidance and reduce the need for saturation biopsy.
Trial Registration Number: NCT03187990, 15/06/2017.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560591 | PMC |
| http://dx.doi.org/10.1007/s00259-021-05599-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
First report of causing leaf spot on in China.
Plant Dis
December 2024
College of Agriculture, Inner Mongolia Minzu University, Tongliao 028000, P. R. China;
Fangfeng (Saposhnikovia divaricata) is a perennial plant belonging to the Umbelliferae family, and is widely cultivated as a traditional Chinese medicine plant used to treat various diseases in northern China. In August 2022, a widespread leaf spot disease emerged on the Fangfeng leaves across a 2.5-acre farmland located in the Naiman District of Tongliao City, China ( 44°17' N; 121°29' E), where 5,000 acres of Fangfeng had been cultivated.
View Article and Find Full Text PDFAutomatic MRI-TRUS Fusion Technique for Transperineal Biopsy Guidance: From Preoperative Planning to Intraoperative Navigation.
Prostate
December 2024
Senior Department of Urology, The Third Medical Center of Chinese PLA General Hospital, Beijing, China.
Background: Targeted and systematic transperineal biopsy of lesions guided by magnetic resonance imaging (MRI) and transrectal ultrasonography (TRUS) fusion technique may optimize the biopsy procedure and enhance the detection of prostate cancer. We described the transperineal biopsy guided by an automatic MRI-TRUS fusion technique, and evaluated the accuracy and feasibility of this method in a prospective single-center study.
Methods: The proposed method focuses on automating the delineation of prostate contours in both the MRI and TRUS images, the registration and fusion of MRI and TRUS images, the generation and visualiztion of the systematic biopsy cores in their corresponding locations within the 2D and the 3D views, as well as the computation and visualiztion of needle trajectories from preoperative planning to intraoperative navigation.
Spatial distributions and source identification of PCDD/Fs and PCBs in soils and pine needles in the multi-industrial city of Ulsan, South Korea.
Chemosphere
December 2024
Department of Civil, Urban, Earth, and Environmental Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea. Electronic address:
The spatial distribution and contamination patterns of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) in soil and pine needles from the multi-industrial city of Ulsan, South Korea were assessed. The mean concentrations of Σ PCDD/Fs, Σ dl-PCBs, and Σ I-PCBs were 78 pg/g dw, 90 pg/g dw, and 453 pg/g dw in the soil and 6 pg/g ww, 31 pg/g ww, and 166 pg/g ww in the pine needles, respectively. The mean concentrations of PCDD/Fs, dl-PCBs, and I-PCBs in the soil at industrial sites (138, 184, and 453 pg/g dw) were significantly higher than those at urban (47, 33, and 186 pg/g dw) and suburban sites (48, 49, and 234 pg/g dw).
View Article and Find Full Text PDFUnlabelled: It is imperative to identify patients with prostate cancer (PCa) who will benefit from androgen receptor signaling inhibitors that can impact quality of life upon prolonged use. Using our extensively-validated artificial-intelligence technique: cellular morphometric biomarker via machine learning (CMB-ML), we identified 13 CMBs from whole slide images of needle biopsies from the trial specimens ( NCT02430480 , n=37) that accurately predicted response to neoadjuvant androgen deprivation therapy (NADT) (AUC: 0.980).
View Article and Find Full Text PDFA Narrative Review of Image Processing Techniques Related to Prostate Ultrasound.
Ultrasound Med Biol
February 2025
Medical UltraSound Image Computing (MUSIC) Lab, Smart Medical Imaging, Learning and Engineering (SMILE) Lab, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, China. Electronic address:
Prostate cancer (PCa) poses a significant threat to men's health, with early diagnosis being crucial for improving prognosis and reducing mortality rates. Transrectal ultrasound (TRUS) plays a vital role in the diagnosis and image-guided intervention of PCa. To facilitate physicians with more accurate and efficient computer-assisted diagnosis and interventions, many image processing algorithms in TRUS have been proposed and achieved state-of-the-art performance in several tasks, including prostate gland segmentation, prostate image registration, PCa classification and detection and interventional needle detection.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!