AI Article Synopsis

  • A new compound called calix[]triazolium was created that specifically detects AMP (adenosine monophosphate).
  • The compound binds with chromenolate anions to form a non-fluorescent complex that can then switch to a fluorescent state when AMP is present.
  • This system effectively differentiates AMP from similar molecules like ADP and ATP based on fluorescence changes, making it unique in its sensing capabilities.

Article Abstract

A novel calix[]triazolium was synthesized and exhibited excellent selectivity for AMP. The binding between calix[]triazolium and chromenolate anions forms a non-fluorescent complex and the resulting supramolecular ensemble selectively detects AMP in water and induces "turn-on" fluorescence. The sensing platform is the first macrocyclic system to discriminate AMP from ADP and ATP through fluorescence changes.

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http://dx.doi.org/10.1039/d1cc04950jDOI Listing

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Since adenosine monophosphate (AMP) is closely related to many diseases, the measurement of AMP is important for the diagnosis and treatment of related diseases. Among the AMP sensors reported thus far, sensors that selectively recognize AMP, not ADP or ATP, are rare, and complex experimental procedures and additional instruments are required for AMP recognition. We developed a colorimetric chemosensor using calix[6]triazolium (CT6) and intended to use it for the simple and rapid detection of AMP.

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Article Synopsis
  • A new compound called calix[]triazolium was created that specifically detects AMP (adenosine monophosphate).
  • The compound binds with chromenolate anions to form a non-fluorescent complex that can then switch to a fluorescent state when AMP is present.
  • This system effectively differentiates AMP from similar molecules like ADP and ATP based on fluorescence changes, making it unique in its sensing capabilities.
View Article and Find Full Text PDF

A triazolium-anthracenyl calix[4]arene conjugate (L) was synthesized by methylating the precursor triazole derivative and then characterized. The potential of the cationic L to differentiate nucleoside triphosphates (NTPs) from their mono- and diphosphates was demonstrated. Due to its unique combination of arms with the calix-platform, a fluorescence enhancement was observed for L with all the NTPs, whereas there is no report with such enhancement being exhibited in case of all the NTPs.

View Article and Find Full Text PDF

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