Judicious substrate design allows interruption of the classical Bischler-Napieralski reaction, providing access to a range of diversely substituted tetracyclic spiroindolines. These complex polycyclic scaffolds are valuable building blocks for the construction of indole alkaloids, as showcased in a concise total synthesis of (±)-akuammicine.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600370 | PMC |
| http://dx.doi.org/10.1039/d1ob01966j | DOI Listing |
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