A formal biomimetic synthesis of (+)-hippolachnin A has been achieved under the guidance of its plausible biosynthetic pathway. Pivotal transformations include an intriguing O-mediated [4 + 2] cycloaddition and a tandem Kornblum-DeLaMare rearrangement/hemiketalization/dehydration reaction. The current work not only offers a unified approach to access skeletally diverse plakortin-type polyketides but also provides convincing evidence to elucidate their underlying biosynthetic network.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.1c03280 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Caterpillar-Inspired Multi-Gait Generation Method for Series-Parallel Hybrid Segmented Robot.
Biomimetics (Basel)
December 2024
College of Mechanical and Electrical Engineering, Xi'an University of Architecture and Technology, Xi'an 710055, China.
The body structures and motion stability of worm-like and snake-like robots have garnered significant research interest. Recently, innovative serial-parallel hybrid segmented robots have emerged as a fundamental platform for a wide range of motion modes. To address the hyper-redundancy characteristics of these hybrid structures, we propose a novel caterpillar-inspired Stable Segment Update (SSU) gait generation approach, establishing a unified framework for multi-segment robot gait generation.
View Article and Find Full Text PDFRobot Task-Constrained Optimization and Adaptation with Probabilistic Movement Primitives.
Biomimetics (Basel)
December 2024
State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin 150001, China.
Enabling a robot to learn skills from a human and adapt to different task scenarios will enable the use of robots in manufacturing to improve efficiency. Movement Primitives (MPs) are prominent tools for encoding skills. This paper investigates how to learn MPs from a small number of human demonstrations and adapt to different task constraints, including waypoints, joint limits, virtual walls, and obstacles.
View Article and Find Full Text PDFBiomimetic tubular materials: from native tissues to a unifying view of new vascular, tracheal, gastrointestinal, oesophageal, and urinary grafts.
Chem Soc Rev
November 2024
Laboratoire de Chimie de la Matière Condensée de Paris, Sorbonne Université, UMR 7574, Paris 75005, France.
Repairing tubular tissues-the trachea, the esophagus, urinary and gastrointestinal tracts, and the circulatory system-from trauma or severe pathologies that require resection, calls for new, more effective graft materials. Currently, the relatively narrow family of materials available for these applications relies on synthetic polymers that fail to reproduce the biological and physical cues found in native tissues. Mimicking the structure and the composition of native tubular tissues to elaborate functional grafts is expected to outperform the materials currently in use, but remains one of the most challenging goals in the field of biomaterials.
View Article and Find Full Text PDFHydrodynamic Simulation and Experiment of a Self-Adaptive Amphibious Robot Driven by Tracks and Bionic Fins.
Biomimetics (Basel)
September 2024
College of Intelligence Science and Technology, National University of Defense Technology, Changsha 410073, China.
Amphibious robots have broad prospects in the fields of industry, defense, and transportation. To improve the propulsion performance and reduce operation complexity, a novel bionic amphibious robot, namely AmphiFinbot-II, is presented in this paper. The swimming and walking components adopt a compound drive mechanism, enabling simultaneous control for the rotation of the track and the wave-like motion of the undulating fin.
View Article and Find Full Text PDFSaponin is Essential for the Isolation of Proteins and RNA from Biological Nanoparticles.
Anal Chem
October 2024
Laboratory of Genetic Technologies, Martsinovsky Institute of Medical Parasitology, Tropical and Vector-Borne Diseases, First Moscow State Medical University (Sechenov University), Moscow 119991, Russia.
Extracellular vesicles (EVs), biomimetics, and other biological nanoparticles (BNs) produced from human cells are gaining increasing attention in the fields of molecular diagnostics and nanomedicine for the delivery of therapeutic cargo. In particular, BNs are considered prospective delivery vehicles for different biologics, including protein and RNA therapeutics. Moreover, EVs are widely used in molecular diagnostics for early detection of disease-associated proteins and RNA.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!