The COVID-19 pandemic exposed numerous challenges in the emergency management (EM) response system. The article contends that had EM deliberately and systematically engaged in systems thinking; it would have been better able to anticipate and respond to many of the challenges. Reasons for EM not fully embracing systems thinking are discussed, including the perception that it is complex and theoretical. This article attempts to dispel these beliefs by first demonstrating how many systems-thinking concepts are already embedded in the EM ethos and then by illustrating the application of system principles in the context of the COVID-19 response. This article concludes by recommending EM invest in training to encourage the systematic application of system principles in emergency preparedness and response.
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http://dx.doi.org/10.5055/jem.0607 | DOI Listing |
Ann Hematol
December 2024
Department of Medical Oncology, Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, Affiliated Hospital of Hebei University, 212 Yuhua East Road, Baoding, 071000, Hebei, China.
The first-line treatment for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) has recently undergone major changes, and targeted therapies have ushered in a new era of CLL/SLL treatment. Scientists in different countries have successively analyzed the efficacy of various drugs, but safety studies are relatively insufficient. Therefore, this systematic evaluation and retrospective meta-analysis was conducted to compare the differences in adverse effects and their incidence among first-line treatment regimens for CLL/SLL.
View Article and Find Full Text PDFAppl Microbiol Biotechnol
December 2024
Life Sciences and Bioengineering Center, Department of Chemical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA.
Transcriptomics is a powerful approach for functional genomics and systems biology, yet it can also be used for genetic part discovery. Here, we derive constitutive and light-regulated promoters directly from transcriptomics data of the basidiomycete red yeast Xanthophyllomyces dendrorhous CBS 6938 (anamorph Phaffia rhodozyma) and use these promoters with other genetic elements to create a modular synthetic biology parts collection for this organism. X.
View Article and Find Full Text PDFLangmuir
December 2024
Department of Physics, National Institute of Technology, Jamshedpur-831014, India.
We have conducted a systematic study employing density functional theory (DFT) and quantum theory of atoms in molecules (QTAIM) to explore the gas sensing capabilities of nitrogen-doped single vacancy graphene quantum dots (SV/3N) decorated with transition metals (TM = Mn, Co, Cu). We have studied the interactions between TM@SV/3N and four different target gases (AsH, NH, PH, and HS) through the computation of adsorption energies, charge transfer, noncovalent interaction, density of states, band gap, and work function for 12 distinct adsorption systems. Our comprehensive analysis included an in-depth assessment of sensors' stability, sensitivity, selectivity, and reusability for practical applications.
View Article and Find Full Text PDFBiometrics
October 2024
RAND Corporation, Pittsburgh, PA 15213, United States.
Health care decisions are increasingly informed by clinical decision support algorithms, but these algorithms may perpetuate or increase racial and ethnic disparities in access to and quality of health care. Further complicating the problem, clinical data often have missing or poor quality racial and ethnic information, which can lead to misleading assessments of algorithmic bias. We present novel statistical methods that allow for the use of probabilities of racial/ethnic group membership in assessments of algorithm performance and quantify the statistical bias that results from error in these imputed group probabilities.
View Article and Find Full Text PDFTree Physiol
December 2024
Department of Forest Ecology and Management, Swedish University of Agricultural Sciences, SE-901 83 Umeå.
Isotopic pulse-labelling of photosynthate allows tracing of carbon (C) from tree canopies to belowground biota and calculations of its turnover in roots and recipient soil microorganisms. A high concentration of label is desirable, but is difficult to achieve in field studies of intact ecosystem patches with trees. Moreover, root systems of trees overlap considerably in most forests, which requires a large labelled area to minimize the impact of C allocated belowground by un-labelled trees.
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