Memristors show great promise in neuromorphic computing owing to their high-density integration, fast computing and low-energy consumption. However, the non-ideal update of synaptic weight in memristor devices, including nonlinearity, asymmetry and device variation, still poses challenges to the learning of memristors, thereby limiting their broad applications. Although the existing offline learning schemes can avoid this problem by transferring the weight optimization process into cloud, it is difficult to adapt to unseen tasks and uncertain environments. Here, we propose a bi-level meta-learning scheme that can alleviate the non-ideal update problem, and achieve fast adaptation and high accuracy, named Rapid One-step Adaption (ROA). By introducing a special regularization constraint and a dynamic learning rate strategy for learning, the ROA method effectively combines offline pre-training and online rapid one-step adaption. Furthermore, we implemented it on memristor-based neural networks to solve few-shot learning tasks, proving its superiority over the pure offline and online schemes under noisy conditions. This method can solve learning in non-ideal memristor networks, providing potential applications of on-chip neuromorphic learning and edge computing.
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http://dx.doi.org/10.3389/frai.2021.692065 | DOI Listing |
Palliat Support Care
January 2025
Department of Theology and Religious Education, College of Liberal Arts, Manila, Philippines.
Teaching death, spirituality, and palliative care equips students with critical skills and perspectives for holistic patient care. This interdisciplinary approach fosters empathy, resilience, and personal growth while enhancing competence in end-of-life care. Using experiential methods like simulations and real patient interactions, educators bridge theory and practice.
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January 2025
Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
Objectives: Explore humanitarian healthcare professionals' (HCPs) perceptions about implementing children's palliative care and to identify their educational needs and challenges, including learning topics, training methods, and barriers to education.
Methods: Humanitarian HCPs were interviewed about perspectives on children's palliative care and preferences and needs for training. Interviews were transcribed, coded, and arranged into overarching themes.
Brief Bioinform
November 2024
School of Engineering, Westlake University, No. 600 Dunyu Road, 310030 Zhejiang, P.R. China.
Single-cell RNA sequencing (scRNA-seq) offers remarkable insights into cellular development and differentiation by capturing the gene expression profiles of individual cells. The role of dimensionality reduction and visualization in the interpretation of scRNA-seq data has gained widely acceptance. However, current methods face several challenges, including incomplete structure-preserving strategies and high distortion in embeddings, which fail to effectively model complex cell trajectories with multiple branches.
View Article and Find Full Text PDFBrief Bioinform
November 2024
Biotherapeutics Molecule Discovery, Boehringer Ingelheim Pharmaceutical Inc., 900 Ridgebury Road, Ridgefield, CT 06877, United States.
Antibody generation requires the use of one or more time-consuming methods, namely animal immunization, and in vitro display technologies. However, the recent availability of large amounts of antibody sequence and structural data in the public domain along with the advent of generative deep learning algorithms raises the possibility of computationally generating novel antibody sequences with desirable developability attributes. Here, we describe a deep learning model for computationally generating libraries of highly human antibody variable regions whose intrinsic physicochemical properties resemble those of the variable regions of the marketed antibody-based biotherapeutics (medicine-likeness).
View Article and Find Full Text PDFAccurate survival prediction of patients with long-bone metastases is challenging, but important for optimizing treatment. The Skeletal Oncology Research Group (SORG) machine learning algorithm (MLA) has been previously developed and internally validated to predict 90-day and 1-year survival. External validation showed promise in the United States and Taiwan.
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