The main differential diagnosis of leukodystrophy associated with macrocephaly consists of Alexander disease, Canavan disease, and megalencephalic leukodystrophy with subcortical cysts. Distinguishing imaging characteristics of Alexander disease are an apicoposterior gradient of white matter involvement and a periventricular T2-hypointense rim.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533653 | PMC |
| http://dx.doi.org/10.5334/jbsr.2588 | DOI Listing |
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