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Microwave-assisted organic reaction enhancement (MORE) has become more important in synthetic organic chemistry for efficient resource utilization. In this study, we synthesized bioactive compounds using both traditional and microwave methods. Microwave-assisted synthesis takes less time and produces higher yields and quality than conventional approaches. We reported the synthesis of '-(1-(2-(3-(4-chlorophenyl)-1-phenyl-1-pyrazol-4-yl)-5-phenyl-1,3,4-oxadiazol-3(2)-yl)ethylidene) substituted hydrazides (-). We also tested them against two strains: HRa and BCG. Against HRa, the compounds , , , , and were the most effective. Compounds , , and showed significant activity against BCG. The structures of newly synthesized molecules were determined using spectral methods. Furthermore, molecular docking investigations into the active site of mycobacterial InhA yielded well-clustered solutions for these compounds' binding modalities producing a binding affinity in the range of -10.366 to -8.037. Theoretical results were in good accord with the observed experimental values. The docking score of compound was -10.366, and the Glide energy was -66.459 kcal/mol.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552481 | PMC |
| http://dx.doi.org/10.1021/acsomega.1c04411 | DOI Listing |
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