AI Article Synopsis
- Kawasaki disease (KD) is a rare childhood vasculitis, and this study presents a case of KD shock syndrome in a 16-month-old infant exhibiting symptoms like high fever and a distinctive rash.
- The infant experienced neurological issues including altered consciousness, leading to MRI scans that showed inflammation in the brain regions not typically associated with KD, such as the anterior perforated substance and hypothalamus.
- This case is significant as it highlights unique neuroradiological findings in KD that are distinct from the usual cerebral vasculitis and may relate to recent observations of inflammatory syndromes linked to COVID-19 in children.
Article Abstract
Kawasaki disease (KD) is a childhood vasculitis of unknown etiology. The present study describes a case of KD shock syndrome that occurred in an infant (age, 16 months) following 7 days of high fever and persistent rash characterized by target-like and purpuric skin lesions. The child developed neurological manifestations such as altered consciousness and irritability. Consequently, brain magnetic resonance imaging (MRI) was performed, revealing an inflammatory involvement of the anterior perforated substance and the hypothalamus. Cerebral involvement on brain MRI is rarely described in KD but when reported is characterized mostly by cerebral vasculitis. We illustrate for the first time in KD an inflammation in the brain not related to vasculitis, reporting peculiar neuroradiological findings. This last aspect has fascinated us in light of recent evidence about the immunological spectrum of Multisystem Inflammatory Syndrome in Children (MIS-C) and Kawasaki-like syndrome in the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outbreak.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555708 | PMC |
| http://dx.doi.org/10.3389/fped.2021.651457 | DOI Listing |
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