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Background: Neurofilament light chain (NFL), a potential biomarker of multiple system atrophy (MSA), has been reported in several studies.
Objectives: The objective of this study was to investigate whether plasma NFL levels are correlated with the progression of motor and cognition function in MSA.
Methods: Patients with MSA were part of a prospective cohort study with assessments at baseline and after 1 year. Plasma NFL was quantified using ultrasensitive Simoa technology.
Results: A total of 91 patients with MSA and 60 healthy controls (HCs) were enrolled. NFL levels increased from baseline to 1-year follow-up (P = 0.010). Baseline plasma NFL levels were significantly associated with motor severity and progression in patients with MSA (P < 0.05) but not with cognitive progression (P > 0.05).
Conclusions: Plasma NFL is a reliable biomarker for the disease severity of MSA and monitoring the progression of MSA, but not the progression of cognition. © 2021 International Parkinson and Movement Disorder Society.
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| http://dx.doi.org/10.1002/mds.28847 | DOI Listing |
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