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Pathogenetic Mechanisms Linking Sarcoidosis to Lymphoma.
Int J Mol Sci
January 2025
Department of Respiratory Medicine, Medical School, Democritus University of Thrace, University General Hospital Dragana, 68100 Alexandroupolis, Greece.
Sarcoidosis and lymphoma share immunopathological characteristics that suggest a complex, interconnected relationship. This article examines the multi-faceted mechanisms linking sarcoidosis to lymphoma, a phenomenon called sarcoidosis-lymphoma syndrome (SLS). SLS is hard to diagnose, requiring distinct criteria and imaging to differentiate overlapping features and histological differences.
View Article and Find Full Text PDFThe cyclin-dependent kinase inhibitor AT7519 is a human RORγt agonist.
Immunol Cell Biol
January 2025
Laboratory of Epigenetics, Institute of Medical Biology, Polish Academy of Sciences, Łódź, Poland.
AT7519, which inhibits multiple cyclin-dependent kinases, has been extensively investigated in various types of cancer cells. Previous studies have demonstrated the ability of this molecule to suppress the expression of the nuclear receptor retinoic acid-related orphan receptor gamma (RORγ) and several genes involved in hepatocellular carcinoma progression. In this study, we identified a distinct agonistic effect of AT7519 on RORγt, an isoform expressed by various immune cells, including T helper 17 lymphocytes.
View Article and Find Full Text PDFAtomic Imaging of the Surface Termination and Reconstruction of Low and High Index Iridium Oxide Surfaces and Insights into Their Facet-Dependent Oxygen Evolution Activities.
ACS Appl Mater Interfaces
January 2025
Institute of Materials Research, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, Guangdong, PR China.
Resolving the atomic surface structure, particularly surface termination or reconstruction, is essential for understanding the catalytic properties of metal oxides. Although rutile phase iridium dioxide (IrO) is the state-of-the-art electrocatalyst for the oxygen evolution reaction (OER) in water splitting, the atomic-level surface structures of IrO remain largely unexplored, limiting our understanding of its facet-dependent OER activities. Herein, we perform aberration-corrected integrated differential phase contrast scanning transmission electron microscopy of the low- and high-index surface structures of spindle-shaped IrO nanorods and reveal distinct surface terminations and/or reconstructions on different surfaces.
View Article and Find Full Text PDFMembrana preformativa: Unveiling the unexplored facets of dental development.
J Oral Biol Craniofac Res
December 2024
Department of Oral Biology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, 600077, India.
Aim: Odontogenesis is a complex and highly regulated biological process that involves a range of molecular mechanisms. Among these, Ki67 and Cyclin D1 are crucial cell cycle regulators that play pivotal roles in controlling cell proliferation during tooth development. This study aims to provide detailed insights into the expression patterns and functional significance of Ki67 and Cyclin D1 in tooth development.
View Article and Find Full Text PDFSocial Vulnerability and Biological Aging in New York City: An Electronic Health Records-Based Study.
J Urban Health
January 2025
Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1057, New York, NY, 10029, USA.
Chronological age is not an accurate predictor of morbidity and mortality risk, as individuals' aging processes are diverse. Phenotypic age acceleration (PhenoAgeAccel) is a validated biological age measure incorporating chronological age and biomarkers from blood samples commonly used in clinical practice that can better reflect aging-related morbidity and mortality risk. The heterogeneity of age-related decline is not random, as environmental exposures can promote or impede healthy aging.
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