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Structure of water-soluble polysaccharides in spore of Ganoderma lucidum and their anti-inflammatory activity. | LitMetric

Structure of water-soluble polysaccharides in spore of Ganoderma lucidum and their anti-inflammatory activity.

Food Chem

Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Published: March 2022

Ganoderma lucidum spore is widely accepted as functional food. Polysaccharides are the predominant bioactive components in G. lucidum spore and contribute much to its health benefits. However, their structural characteristics remain unclear. In this work, water-soluble polysaccharides (GLSP) were obtained by hot water extraction. Three monosaccharides, including arabinose (Ara), glucose (Glc) and galactose (Gal), were presented in GLSP. 1D and 2D NMR data revealed that GLSP were composed mainly by two polysaccharides, β-glucan and arabinogalactan. The arabinogalactan had a backbone of galactan with Araf in the side chain. β-Glucan was the dominant polysaccharide in G. lucidum spore. The molecular weight was measured. GLSP could induce IEC-6 cells proliferation in a concentration-dependent manner. Moreover, GLSP possessed a strong anti-inflammatory activity through inhibiting the overproduction of NO and pro-inflammatory cytokines, like interleukin-6 (IL-6) and interleukin-1β (IL-1β) induced by LPS. These results implied the potential of GLSP on gut barrier protection.

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Source
http://dx.doi.org/10.1016/j.foodchem.2021.131374DOI Listing

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