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A Systematic Targeted Genetic Screen Identifies Proteins Involved in Cytoadherence of the Malaria Parasite P. falciparum.
Mol Microbiol
January 2025
Department of Biochemistry and Molecular Biology, Justus-Liebig University Gießen, Gießen, Germany.
Immediately after invading their chosen host cell, the mature human erythrocyte, malaria parasites begin to export an array of proteins to this compartment, where they initiate processes that are prerequisite for parasite survival and propagation, including nutrient import and immune evasion. One consequence of these activities is the emergence of novel adhesive phenotypes that can lead directly to pathology in the human host. To identify parasite proteins involved in this process, we used modern genetic tools to target genes encoding 15 exported parasite proteins, selected by an in silico workflow.
View Article and Find Full Text PDFThe ghost of selective inference in spatiotemporal trend analysis.
Sci Total Environ
January 2025
Institute of Natural Resources and Agrobiology of Seville (IRNAS), Spanish National Research Council (CSIC), Av. Reina Mercedes 10, 41012 Seville, Spain. Electronic address:
In spatiotemporal trend analysis, selective inference occurs when researchers are only interested in significant trends based on a fixed threshold (α, often 0.05), without considering the total number of statistical tests performed. Using simultaneous inference in gridded data involves thousands of trend tests, one for each pixel, leading to multiple testing or multiplicity problems.
View Article and Find Full Text PDFEffect of supplementation with lutein, zeaxanthin, and omega-3 fatty acids on macular pigment and visual function in young adults with long-term use of digital devices: study protocol for a randomized double-blind placebo-controlled study.
Front Nutr
October 2024
School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Background: Growing evidence emphasizes the importance of xanthophyll carotenoids and omega-3 fatty acids in eye health. However, the beneficial effects of such supplementation have not been thoroughly discussed among adults with high screen exposure. Current trial evidence on lutein bioavailability is contradictory, and the interactions of dietary intervention with host-related factors remain elusive.
View Article and Find Full Text PDFPupillary Peaking & Presence of Dysphotopsias Following Glaucoma Tube Shunt Surgery.
Semin Ophthalmol
October 2024
Institute of Ophthalmology & Visual Science, Rutgers New Jersey Medical School, Newark, NJ, USA.
Purpose: To describe the presence of pupillary peaking and dysphotopsias in a sample of eyes following glaucoma drainage device (GDD) surgery.
Methods: Cross-sectional analysis of 68 glaucoma patients with GDD, 45 patients with glaucoma and no GDD, and 50 control patients was conducted in a single academic center. Patients with an appropriate diagnosis that met the inclusion criteria were asked to enroll in the study.
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