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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850225 | PMC |
| http://dx.doi.org/10.1007/s00417-021-05462-z | DOI Listing |
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Comment on Accuracy of Toric Intraocular Lens Formulas With Measured Posterior Corneal Astigmatism of Different Orientations.
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Universidad Autonoma de Bucaramanga UNAB, Bucaramanga, Colombia.
Reply to Comment on Accuracy of Toric Intraocular Lens Formulas With Measured Posterior Corneal Astigmatism of Different Orientations.
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Predictive Power of Polygenic Risk Scores for Intraocular Pressure or Vertical Cup-Disc Ratio.
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Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Importance: Early detection of glaucoma is essential to timely monitoring and treatment, and primary open-angle glaucoma risk can be assessed by measuring intraocular pressure (IOP) or optic nerve head vertical cup-disc ratio (VCDR). Polygenic risk scores (PRSs) could provide a link between genetic effects estimated from genome-wide association studies (GWASs) and clinical applications to provide estimates of an individual's genetic risk by combining many identified variants into a score.
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Performance of Polygenic Risk Scores for Primary Open-Angle Glaucoma in Populations of African Descent.
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Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Importance: Primary open-angle glaucoma (POAG) polygenic risk scores (PRSs) continue to be evaluated in primarily European-ancestry populations despite higher prevalence and worse outcomes in African-ancestry populations.
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Design, Setting, And Participants: This was a multicenter, cross-sectional study of POAG cases and controls from Tanzania, South Africa, Nigeria, Ghana, and the US.
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