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Clinical outcomes and cost-effectiveness of COVID-19 vaccination in South Africa. | LitMetric

AI Article Synopsis

  • Low- and middle-income countries are facing challenges in COVID-19 vaccination efforts due to varying vaccine effectiveness, high costs, supply shortages, and limited resources.
  • A microsimulation model assessing South Africa’s vaccination program showed that vaccinating at least 40% of the population could significantly prevent infections and deaths, while also lowering healthcare costs.
  • The success of vaccination programs is more heavily influenced by factors like prompt procurement and distribution rather than just the characteristics of the vaccines themselves.

Article Abstract

Low- and middle-income countries are implementing COVID-19 vaccination strategies in light of varying vaccine efficacies and costs, supply shortages, and resource constraints. Here, we use a microsimulation model to evaluate clinical outcomes and cost-effectiveness of a COVID-19 vaccination program in South Africa. We varied vaccination coverage, pace, acceptance, effectiveness, and cost as well as epidemic dynamics. Providing vaccines to at least 40% of the population and prioritizing vaccine rollout prevented >9 million infections and >73,000 deaths and reduced costs due to fewer hospitalizations. Model results were most sensitive to assumptions about epidemic growth and prevalence of prior immunity to SARS-CoV-2, though the vaccination program still provided high value and decreased both deaths and health care costs across a wide range of assumptions. Vaccination program implementation factors, including prompt procurement, distribution, and rollout, are likely more influential than characteristics of the vaccine itself in maximizing public health benefits and economic efficiency.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556310PMC
http://dx.doi.org/10.1038/s41467-021-26557-5DOI Listing

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