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Machine learning-based prediction of disease progression in primary progressive multiple sclerosis.
Brain Commun
January 2025
Multiple Sclerosis Center, Sheba Medical Center, Ramat-Gan 5262, Israel.
Primary progressive multiple sclerosis (PPMS) affects 10-15% of multiple sclerosis patients and presents significant variability in the rate of disability progression. Identifying key biological features and patients at higher risk for fast progression is crucial to develop and optimize treatment strategies. Peripheral blood cell transcriptome has the potential to provide valuable information to predict patients' outcomes.
View Article and Find Full Text PDFEfficacy and safety of the PHIL embolic agent in the treatment of intracranial dural arteriovenous fistulas: results of the PHIL-dAVF study.
J Neurointerv Surg
January 2025
Diagnostic and Therapeutic Neuroradiology, Hôpital Purpan, Toulouse, France.
Background And Purpose: Embolization is the first-line treatment for dural arteriovenous fistulas (dAVF). The precipitating hydrophobic injectable liquid (PHIL) embolic agent is a non-adhesive copolymer with specific features and endovascular behavior. This study assessed its safety and efficacy in a prospective real-life cohort.
View Article and Find Full Text PDFNurse practitioner and physician associate mentorship: Improving retention and employment experiences.
J Am Assoc Nurse Pract
January 2025
Providence Swedish Medical Group.
Background: Clinician turnover is costly for health care organizations.
Local Problem: A retention strategy for newly hired nurse practitioners (NPs) and physician associates (PAs) was needed at our organization.
Methods: A quality improvement project was conducted to determine whether a mentorship program could improve retention and employment experiences of newly hired NPs and PAs.
Effectiveness of Virtual Reality Training in Improving Outcomes for Dialysis Patients: Systematic Review and Meta-Analysis.
J Med Internet Res
January 2025
Department of Center for Hemodialysis, The Second Hospital of Dalian Medical University, Dalian, China.
Background: Virtual reality (VR) training uses computer-generated simulations that enable users to engage with immersive virtual environments, simulating real-world activities or therapeutic exercises. This technology is increasingly recognized as a promising intervention to address the physical and psychological challenges faced by dialysis patients, who frequently experience diminished physical function, social isolation, and emotional distress associated with prolonged treatment regimens. Given the increasing prevalence of dialysis patients and the limitations of conventional rehabilitation approaches, VR presents a novel, interactive method that has the potential to enhance patient well-being and improve quality of life.
View Article and Find Full Text PDFThe Role of the Serotonergic System in Time Perception: A Systematic Review.
Int J Mol Sci
December 2024
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117465 Moscow, Russia.
Time perception is a fundamental cognitive function essential for adaptive behavior and shared across species. The neural mechanisms underlying time perception, particularly its neuromodulation, remain debated. In this review, we examined the role of the serotonergic system in time perception (at the scale of seconds and minutes), building a translational bridge between human and non-human animal studies.
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