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http://dx.doi.org/10.1016/j.brs.2021.10.389 | DOI Listing |
ACS Appl Bio Mater
January 2025
Regenerative Medicine and Stem Cell Laboratory (RMS), Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi 502 284, Telangana, India.
Despite advancements in chronic arthritis treatment, there remains a significant demand for advanced nanotechnologies capable of efficiently delivering a wide range of therapeutic agents to provide symptomatic relief and facilitate the healing of inflamed cartilage tissue. Considering the significant impact of hypoxia on the development and maintenance of chondral tissue, replicating its effects on stem cells could be a potential approach for the treatment of osteoarthritis (OA). Cobalt is a prominent hypoxia-inducing agent, owing to its ability to activate the hypoxia-inducible factor (HIF) pathway regardless of cellular oxygen levels.
View Article and Find Full Text PDFReumatologia
December 2024
Óbuda University, Budapest, Hungary.
Introduction: Osteoarthritis (OA) presents significant challenges, imposing limitations on patients' daily activities. Factors such as restricted mobility, sedentary lifestyles, social isolation, and weight gain can exacerbate the difficulties faced by these individuals. Our study aimed to identify the needs and personal challenges faced by individuals with OA, and the impact of the COVID-19 pandemic.
View Article and Find Full Text PDFLife (Basel)
January 2025
Faculty of Medicine and Pharmacy, "Dunărea de Jos" University of Galați, 800201 Galați, Romania.
Background: Colonic obstructions present a serious medical emergency that requires prompt surgical intervention to prevent life-threatening complications. Cecostomy, a procedure involving the creation of an opening in the cecum to decompress the colon, serves as one surgical approach for managing these obstructions. The aim of this review is to evaluate the effectiveness and benefits of cecostomies in emergency surgical settings, with a focus on recent clinical studies and case reports.
View Article and Find Full Text PDFFront Sports Act Living
January 2025
Shanghai Normal University, Sport Department, Shanghai, China.
The rapid development of prepaid consumption in China's sports industry has been hindered by fundamental issues such as operators' blind expansion, lack of transparency in business information, absence of standard contract texts, and inadequate consumer rights protection. These challenges have led to business closures, unfair contract terms, difficulties in card refunds and transfers, and the excessive issuance of long-term or lifetime prepaid cards. These problems severely damage the industry's integrity and impede its healthy and sustainable development.
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