Peri-implantitis, systemic inflammation, and dyslipidemia: a cross-sectional biochemical study.

Purpose: The aim of this study was to compare the inflammatory and lipid profile of patients with and without peri-implantitis.

Methods: A cross-sectional biochemical study was carried out in which blood samples were collected from 16 patients with peri-implantitis and from 31 subjects with healthy implants. Clinical peri-implant parameters were obtained from all subjects. Levels of tumor necrosis factor-alpha and interleukin-10 (IL-10) were measured in serum. Lipid fractions, glucose and creatinine levels, and complete blood count were also assessed.

Results: After controlling for a history of periodontitis, statistically significant differences between peri-implantitis patients and controls were found for total cholesterol (estimated adjusted mean difference, 76.4 mg/dL; 95% confidence interval [CI], 39.6, 113.2 mg/dL; <0.001), low-density lipoprotein (LDL) cholesterol (estimated adjusted mean difference, 57.7 mg/dL; 95% CI, 23.8, 91.6 mg/dL; <0.001), white blood cells (WBC) (estimated adjusted mean difference, 2.8×10/μL; 95% CI, 1.6, 4.0×10/μL; <0.001) and IL-10 (estimated adjusted mean difference, -10.4 pg/mL; 95% CI, -15.8, -5.0 pg/mL; <0.001). The peri-implant probing pocket depth (PPD) was modestly positively correlated with total cholesterol (r=0.512; <0.001), LDL cholesterol (r=0.463; =0.001), and WBC (r=0.519; <0.001). A moderate negative correlation was observed between IL-10 and PPD (r=0.609; <0.001).

Conclusions: Otherwise healthy individuals with peri-implantitis showed increased low-grade systemic inflammation and dyslipidemia.