New nanoparticles (Y6 NPs) based on the A-DA'D-A fused-ring conjugated small molecule Y6 have been prepared for the combined photothermal and photodynamic therapy of cancer. Y6 NPs show excellent light absorption from 300 to 900 nm, a good photothermal conversion efficiency of 57% and reactive oxygen species generation capability. The high photothermal conversion ability and superior photodynamic activity of Y6 NPs endow them with great potential for cancer therapy.
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http://dx.doi.org/10.1039/d1cc04629b | DOI Listing |
J Nanobiotechnology
December 2023
Institute of Geriatrics, Jiangxi Provincial People's Hospital &, The First Affiliated Hospital of Nanchang Medical College, Nanchang, 330006, Jiangxi, People's Republic of China.
Photothermal therapy (PTT) and photodynamic therapy (PDT) are effective method for tumor treatment. However, the limited variety and quantity of photothermal agents (PTAs) and photosensitizer (PSs) are still major challenges. Moreover, the cell apoptosis mechanism induced by PDT and PTT is still elusive.
View Article and Find Full Text PDFJ Am Chem Soc
January 2024
Department of Applied Chemistry, National Yang Ming Chiao Tung University, 1001 University Road, Hsinchu 30010, Taiwan.
The high-performance Y6-based nonfullerene acceptors (NFAs) feature a C-shaped A-DA'D-A-type molecular architecture with a central electron-deficient thiadiazole (Tz) A' unit. In this work, we designed and synthesized a new A-D-A-type NFA, termed CB16, having a C-shaped -benzodipyrrole-based skeleton of Y6 but with the Tz unit eliminated. When processed with nonhalogenated xylene without using any additives, the binary PM6:CB16 devices display a remarkable power conversion efficiency (PCE) of 18.
View Article and Find Full Text PDFACS Appl Mater Interfaces
August 2022
Department of Materials Science and Engineering, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.
Angew Chem Int Ed Engl
July 2022
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
The A-DA'D-A fused-ring electron acceptors with an angular fusion mode and electron-deficient core has significantly boosted organic photovoltaic efficiency. Here, the intrinsic role of the peculiar structure is revealed by comparing representative A-DA'D-A acceptor Y6 with its A-D-A counterparts having different fusion modes. Owing to the more delocalized HOMO and deeper LUMO level, Y6 exhibits stronger and red-shifted absorption relative to the linear and angular fused A-D-A acceptors, respectively.
View Article and Find Full Text PDFChem Commun (Camb)
November 2021
School of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangsu, 226019, P. R. China.
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