Background: Patients with a variety of neuromuscular pathologies may present with gait abnormalities. Accurate assessment of each pattern, coupled with appropriate investigations, facilitates diagnostic accuracy followed by treatment or referral, as required.
Objective: This review outlines the relevant history and examination areas to assess when interpreting gait abnormalities, together with common gait patterns and their aetiologies.
Discussion: A range of factors should be evaluated, including posture, walking aids and footwear. The gait cycle can be broadly divided into the stance and swing phases, and additional features are assessed to identify specific patterns and generate a provisional diagnosis. Gait examination, from the time the patient is called from the waiting room, will help the clinician focus on the relevant systems to examine, investigate and treat.
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http://dx.doi.org/10.31128/AJGP-12-20-5777 | DOI Listing |
Pharmaceuticals (Basel)
December 2024
BK21 FOUR Team and Integrated Research, Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang 10326, Republic of Korea.
Parkinson's disease (PD) is a chronic, progressive neurological disorder affecting approximately 10 million people worldwide, with prevalence expected to rise as the global population ages. It is characterized by the degeneration of dopamine-producing neurons in the substantia nigra pars compacta, leading to motor symptoms such as tremor, rigidity, bradykinesia, postural instability, and gait disturbances, as well as non-motor symptoms including olfactory disturbances, sleep disorders, and depression. Currently, no cure exists for PD, and most available therapies focus on symptom alleviation.
View Article and Find Full Text PDFBioengineering (Basel)
December 2024
School of Biomedical Engineering, Capital Medical University, Beijing 100071, China.
Thigh muscles greatly influence knee joint loading, and abnormal loading significantly contributes to the progression of knee osteoarthritis (KOA). Muscle weakness in KOA patients is common, but the specific contribution of each thigh muscle to joint loading is unclear. The gait data from 10 severe female KOA patients and 10 controls were collected, and the maximum isometric forces of the biceps femoris long head (BFL), semitendinosus (ST), rectus femoris (RF), vastus lateralis (VL), and vastus medialis (VM) were calibrated via ultrasound.
View Article and Find Full Text PDFAnimals (Basel)
December 2024
Sydney School of Veterinary Science, The University of Sydney, Camden, NSW 2570, Australia.
Myotonia congenita is a hereditary, non-dystrophic skeletal muscle disorder associated with muscle stiffness due to delayed muscle relaxation after contraction. We review myotonia congenita in domesticated animals and humans and investigated suspected myotonia congenita in a flock of Merino sheep in Australia. In 2020, a property in New South Wales reported a four-year history of lambs that would fall on disturbance before rapidly recovering, with 13 affected sheep identified in 2020.
View Article and Find Full Text PDFSleep Med
December 2024
Department of Neurology, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, Henan Province, China. Electronic address:
Fatal familial insomnia (FFI) is a rare autosomal dominant neurodegenerative disorder characterized by rapidly progressive dementia, severe sleep disturbances, and autonomic dysfunction. The clinical manifestations of FFI can exhibit substantial variations, making it crucial to rule out other conditions, such as autoimmune encephalitis and Creutzfeldt-Jakob disease, during early diagnosis. In this study, we describe the case of a 58-year-old man who experienced persistent insomnia, autonomic symptoms, gait instability, and rapidly progressive dementia.
View Article and Find Full Text PDFBMC Neurol
January 2025
Faculty of Medicine, Department of Neurology, Al-Quds University, Jerusalem, Palestine.
Background: Vanishing white matter disease (VWMD) is a rare autosomal recessive leukoencephalopathy. It is typified by a gradual loss of white matter in the brain and spinal cord, which results in impairments in vision and hearing, cerebellar ataxia, muscular weakness, stiffness, seizures, and dysarthria cogitative decline. Many reports involve minors.
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