Improvement of Stewart-Treves angiosarcoma through interleukin 23p19 inhibition.

JAAD Case Rep

Department of Dermatology, Grand Hôpital de Charleroi, Charleroi, Belgium.

Published: November 2021

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531457PMC
http://dx.doi.org/10.1016/j.jdcr.2021.09.035DOI Listing

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Article Synopsis
  • Stewart-Treves syndrome (STS) is a rare but aggressive lymphatic sarcoma that can develop in patients with chronic lymphedema, often occurring years after breast cancer treatment, with a low survival rate.
  • A case study of a 74-year-old woman revealed STS manifested 13 years post-breast cancer surgery, leading to rapid progression and requiring significant surgical intervention.
  • Post-surgery chemotherapy improved her condition, and she has lived over 13 months after treatment, enjoying a better quality of life and normal activities with some assistance.
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Stewart-Treves syndrome: Case report and literature review.

Rep Pract Oncol Radiother

October 2020

Department of Oncology and Radiotherapy, Charles University in Prague, Faculty of Medicine and University Hospital in Pilsen, alej Svobody 80, 304 60 Pilsen, Czech Republic.

Lymphangiosarcoma, or Stewart-Treves Syndrome (STS), is a very rare skin angiosarcoma with poor prognosis, which usually affects the upper limbs of patients who underwent breast cancer surgery, including axillary dissection followed by radiotherapy (RT). Cutaneous lymphangiosarcomas, which account for approximately 5% of all angiosarcomas, usually originate in the limb with chronic lymphedema. Lymphatic blockade is involved in the onset of STS.

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Background: Primary and secondary breast angiosarcoma is a rare and aggressive malignancy with limited published literature. Optimal management is mostly based on expert opinion. Our study aims to describe a single institution experience with breast angiosarcoma and evaluate other publications on this topic to further clarify prognostic outcomes and treatment modalities in this disease.

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Pancreatic metastasis of angiosarcoma (Stewart-Treves syndrome) diagnosed using endoscopic ultrasound-guided fine needle aspiration: A case report.

Medicine (Baltimore)

August 2016

Division of Gastroenterology and Hematology/Oncology, Department of Medicine Department of Dermatology, Asahikawa Medical University, Hokkaido Gastroenterology Medicine Center, Shonan Kamakura General Hospital, Kanagawa Center for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan.

Background: Pancreatic involvement of angiosarcoma is extremely rare.

Methods: We herein report a rare case of angiosarcoma associated with chronic lymphedema (Stewart-Treves syndrome) with pancreatic metastasis that was diagnosed using endoscopic ultrasound (EUS)/fine needle aspiration (FNA).

Results: A 43-year-old woman with a history of radical hysterectomy with bilateral inguinal lymphadenectomy and chemoradiotherapy for cervical cancer 15 years prior noticed the presence of erythematous indurative plaques on her right femoral region, where chronic lymphedema had developed.

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