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| http://dx.doi.org/10.34172/mejdd.2021.222 | DOI Listing |
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Single-cell analysis of lung epithelial cells reveals age and cell population-specific responses to SARS-CoV-2 infection in ciliated cells.
Clin Exp Immunol
January 2025
Translational Biomedical Sciences Program, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Introduction: The ability of SARS-CoV-2 to evade antiviral immune signaling in the airway contributes to the severity of COVID-19 disease. Additionally, COVID-19 is influenced by age and has more severe presentations in older individuals. This raises questions about innate immune signaling as a function of lung development and age.
View Article and Find Full Text PDFGut microbiota in post-acute COVID-19 syndrome: not the end of the story.
Front Microbiol
December 2024
Tianjin Key Laboratory of Digestive Diseases, Department of Gastroenterology and Hepatology, Tianjin Institute of Digestive Diseases, National Key Clinical Specialty, General Hospital, Tianjin Medical University, Tianjin, China.
The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has led to major global health concern. However, the focus on immediate effects was assumed as the tip of iceberg due to the symptoms following acute infection, which was defined as post-acute COVID-19 syndrome (PACS). Gut microbiota alterations even after disease resolution and the gastrointestinal symptoms are the key features of PACS.
View Article and Find Full Text PDFA multiplex method for rapidly identifying viral protease inhibitors.
Mol Syst Biol
January 2025
Department of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 10032, USA.
With current treatments addressing only a fraction of pathogens and new viral threats constantly evolving, there is a critical need to expand our existing therapeutic arsenal. To speed the rate of discovery and better prepare against future threats, we establish a high-throughput platform capable of screening compounds against 40 diverse viral proteases simultaneously. This multiplex approach is enabled by using cellular biosensors of viral protease activity combined with DNA-barcoding technology, as well as several design innovations that increase assay sensitivity and correct for plate-to-plate variation.
View Article and Find Full Text PDFThe highly pathogenic strain of porcine deltacoronavirus disrupts the intestinal barrier and causes diarrhea in newborn piglets.
Virulence
December 2025
College of Veterinary Medicine, Northeast Agricultural University, Harbin, PR China.
Article Synopsis
- PDCoV is increasingly affecting newborn piglets, causing diarrhea, and poses significant challenges to the pig industry due to its potential for cross-species transmission.
- A new PDCoV strain was isolated from piglets in China, showing high genetic similarity to other strains and notable amino acid mutations in its S protein that alter its structure and function.
- The study confirmed that this strain damages the intestinal barrier of piglets, leads to clinical symptoms like diarrhea, and lays the groundwork for future vaccine and diagnostic development to combat piglet diarrhea.
Perspective on the Potential Vertical Transmission of SARS-CoV-2 Through Breast Milk.
J Paediatr Child Health
January 2025
College of Osteopathic Medicine, Rocky Vista University, Ivins, Utah, USA.
Aim: SARS-CoV-2 is highly transmissible, having infected ~16 million children in the United States. Symptom severity is higher in infants compared to older children, possibly due to their ineligibility for vaccination. Concerns persist that mothers transmit infectious viral loads of SARS-CoV-2 through breast milk.
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