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Diagnostic Significance of Serum Fatty Acid Synthase in Patients with Pancreatic Cancer. | LitMetric

Diagnostic Significance of Serum Fatty Acid Synthase in Patients with Pancreatic Cancer.

Middle East J Dig Dis

Liver and Pancreatobiliary Diseases Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Published: April 2021

AI Article Synopsis

  • - Pancreatic cancer has a poor prognosis and is the deadliest gastrointestinal cancer, with deregulated pathways frequently involving increased fatty acid synthesis.
  • - A study measured serum fatty acid synthase (FASN) levels in 92 pancreatic cancer patients and 92 healthy controls, finding significantly higher levels in cancer patients and smokers.
  • - The results suggest elevated FASN levels are linked to pancreatic cancer and point to its potential as a diagnostic biomarker due to its role in lipid production for cancer cell survival.

Article Abstract

BACKGROUND Pancreatic cancer is considered as the most deadly tumor among gastrointestinal cancers because of its poor prognosis. The frequently deregulated pathway in the cancer cell is associated with an increased expression of various genes, including the synthesis of fatty acids. We aimed to evaluate the level of serum fatty acid synthase (FASN) as a diagnostic marker for early diagnosis of pancreatic cancer. METHODS Serum FASN levels were measured by ELISA in 92 patients with pancreatic adenocarcinomas and in 92 healthy controls. Logistic regression analysis was used to identify independent predictors of certain diagnostic categories. RESULTS Serum FASN levels were significantly higher in patients with pancreatic cancer than in healthy controls (1.35 [0.98-2.3] ng/mL vs 1.04 [0.19-1.34] ng/mL, < 0.001) and in smokers compared to non-smokers (1.41 [0.79-2.52] ng/mL vs 1.07 [0.21-1.74] ng/mL, < 0.001). FASN levels and smoking were associated with increased risk of PC (1.54 [1.1- 2.14] ng/mL, = 0.011 and 5.69 [2.68-12.09] ng/mL, < 0.001, respectively). CONCLUSION Elevated serum FASN levels in patients with pancreatic cancer indicate the need for the production of large numbers of lipids for the survival and proliferation of human cancer cells and the diagnostic value of FASN as a new diagnostic biomarker.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531924PMC
http://dx.doi.org/10.34172/mejdd.2021.214DOI Listing

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