AI Article Synopsis
- - Respiratory tract infections are a significant health issue for young children, and the microbial communities in different body sites may influence illness risk.
- - This study analyzed the microbial communities in the oral cavity, nasopharynx, and gut of 112 healthy infants during their first six months using advanced sequencing techniques.
- - Results indicate that the interactions among these microbial communities are closely linked to a child's susceptibility to respiratory infections, emphasizing the importance of these connections for respiratory health.
Article Abstract
Respiratory tract infections are a major cause of morbidity and mortality worldwide in young children. Concepts such as the gut-lung axis have highlighted the impact of microbial communities at distal sites in mediating disease locally. However, little is known about the extent to which microbial communities from multiple body sites are linked, and how this relates to disease susceptibility. Here, we combine 16S-based rRNA sequencing data from 112 healthy, term born infants, spanning three body sites (oral cavity, nasopharynx, gut) and the first six months of life. Using a cross-niche microbial network approach, we show that, already from the first week of life on, there is a strong association between both network structure and species essential to these structures (hub species), and consecutive susceptibility to respiratory tract infections in this cohort. Our findings underline the crucial role of cross-niche microbial connections in respiratory health.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553847 | PMC |
| http://dx.doi.org/10.1038/s42003-021-02755-1 | DOI Listing |
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