Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1183/13993003.02241-2021 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Trophoblast-derived factors drive human mesenchymal stem cell differentiation along an endothelial lineage: A model of early placental vasculogenesis.
Reprod Biol
January 2025
Department of Biology, Edge Hill University, L39 4QP, UK. Electronic address:
Mechanisms controlling the process and patterning of blood vessel development in the placenta remain largely unknown. The close physical proximity of early blood vessels observed in the placenta and the cytotrophoblast, as well as the reported production of vasculogenic growth factors by the latter, suggests that signalling between these two niches may be important. Here, we have developed an in vitro model to address the hypothesis that the cytotrophoblast, by the secretion of soluble factors, drives differentiation of resident sub-trophoblastic mesenchymal stem cells (MSCs) along a vascular lineage, thereby establishing feto-placental circulation.
View Article and Find Full Text PDFVE-cadherin shedding in vitro and in patients with aortic aneurysm and dissection.
Sci Rep
November 2024
Clinic for Vascular and Endovascular Surgery, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
VE-cadherin (VEC) is a major endothelial adhesion protein, which controls vascular homeostasis. During vascular diseases, VEC can be shed from the endothelial surface by proteases like ADAM10/17, which cleave the extracellular domain of VEC in response to inflammatory cytokines like TNF-α. The resulting, soluble fragments (sVEC) are discussed as a potential marker for endothelial barrier breakdown.
View Article and Find Full Text PDFAC092100.1 promotes angiogenesis in pre-eclampsia through YTHDC2/VEGFA signaling.
Funct Integr Genomics
September 2024
Department of Obstetrics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Article Synopsis
- Aberrant long non-coding RNA (lncRNA) expression is linked to pre-eclampsia (PE), with specific focus on the lncRNA AC092100.1 to understand its role in angiogenesis in this condition.
- Using bioinformatics and qRT-PCR, researchers confirmed the reduced levels of AC092100.1 in placental tissues of PE patients and studied its effects on endothelial cell functions like proliferation and tube formation.
- The study found that AC092100.1 promotes vascular endothelial growth factor-A (VEGFA) expression by binding to YTHDC2, which helps improve fetal growth and reduce certain negative markers in a PE mouse model.
Coagulation factor XI regulates endothelial cell permeability and barrier function in vitro and in vivo.
Blood
October 2024
Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR.
Article Synopsis
- Loss of endothelial barrier function is linked to inflammatory diseases, and coagulation factor XI (FXI) plays a significant role in this process.
- The study found that FXIa increases endothelial cell permeability by cleaving VE-cadherin, which is involved in cell adhesion.
- This cleavage is mediated by the activation of ADAM10 and leads to a signaling cascade via VEGFR2 that enhances ADAM10 expression, suggesting FXIa could contribute to inflammatory disease development by disrupting the endothelial barrier.
Electrospun polyhedral oligomeric silsequioxane-poly(carbonate-urea) urethane for fabrication of hemocompatible small-diameter vascular grafts with angiogenesis capacity.
Int J Biol Macromol
October 2024
Koç University Research Centre for Translational Medicine (KUTTAM), Koç University School of Medicine, Rumeli Feneri, 34450, Sariyer, Istanbul, Turkey; Biophysics Department, Koç University School of Medicine, Rumeli Feneri, 34450, Sariyer, Istanbul, Turkey.
The clinical utility of small-diameter vascular grafts (SDVGs) is limited due to the possibility of thrombosis and intimal hyperplasia. These features can delay the development of a functional endothelial cell (EC) monolayer on the luminal surface of grafts. Therefore, the development and fabrication of vascular grafts (VGs) with comparable extracellular matrix (ECM) functions are mandatory to elicit hemocompatible confluent EC monolayers, and angiogenesis behavior inside the body.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!