AI Article Synopsis
- Adenomatoid odontogenic tumor (AOT) is a benign tumor commonly found in children and young adults, showing favorable outcomes and requiring minimal treatment.
- The study analyzed 28 cases from 1994-2019 at the University of Florida, highlighting that most patients were under 20 years old, predominantly female, and typically presented with lesions in the anterior jaws.
- The research underscores the need for clinicians to better recognize AOT due to its distinct characteristics and the importance of accurate diagnosis to avoid unnecessary treatments compared to more complex odontogenic conditions.
Article Abstract
Objective: Adenomatoid odontogenic tumor (AOT) is a benign odontogenic tumor with an excellent prognosis, often seen in children and young adults. The aim was to examine the spectrum of clinical, radiographic, and histologic attributes of AOT and assess clinician recognition of this entity. In addition, diagnostic considerations and treatment modalities were explored.
Method And Materials: With Institutional Review Board approval, archival cases of AOT from the University of Florida Oral Pathology Biopsy Service (1994-2019) were examined. Clinical and demographic data along with accompanying radiographs and original slides were reviewed.
Results: A total of 28 cases of AOT were identified. These were all solitary in nature, with a mean age of 20.6 years (range 12-67 years). Most patients were under 20 (75.0%) with a definite female predilection (64.3%). Anterior jaws remained the most common location (85.2%), with a higher maxillary predilection (57.1%). Clinical impression included odontogenic lesions such as dentigerous cyst, lateral periodontal cyst, and odontogenic keratocyst.
Conclusion: The spectrum of features of AOT is described. As clinicians were unfamiliar with AOT, highly characteristic features of AOT and more unique variants are discussed extensively to improve diagnostic aptitude. Clinicians must remain aware of this entity, as treatment is minimal compared to other odontogenic entities.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3290/j.qi.b2218723 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Deciphering odontogenic myxoma: the role of copy number variations as diagnostic signatures.
J Zhejiang Univ Sci B
December 2024
Department of Oral Pathology, Peking University School and Hospital of Stomatology / National Center of Stomatology / National Clinical Research Center for Oral Diseases / National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China.
In light of the lack of reliable molecular markers for odontogenic myxoma (OM), the detection of copy number variation (CNV) may present a more objective method for assessing ambiguous cases. In this study, we employed multiregional microdissection sequencing to integrate morphological features with genomic profiling. This allowed us to reveal the CNV profiles of OM and compare them with dental papilla (DP), dental follicle (DF), and odontogenic fibroma (OF) tissues.
View Article and Find Full Text PDFFactors related to risk of recurrence and recurrence free survival in ameloblastoma of the Jaws: A single centre retrospective analysis.
Oral Maxillofac Surg
December 2024
Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences Institute of Medical Sciences, Banaras Hindu University, Varanasi Uttar Pradesh, 221001, India.
Purpose: Ameloblastoma is a benign tumor originating from odontogenic epithelium with a global incidence of about 0.5 cases per million persons per year. The overall recurrence rate of ameloblastomas range from 55% -90%.
View Article and Find Full Text PDFMetabolic Analysis of Tumor Cells Within Ameloblastoma at the Single-Cell Level.
Oral Dis
December 2024
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
Background: To meet their high energy needs, tumor cells undergo aberrant metabolic reprogramming. A tumor cell may expertly modify its metabolic pathways and the differential expression of the genes for metabolic enzymes. The physiological requirements of the host tissue and the tumor cell of origin mostly dictate metabolic adaptation.
View Article and Find Full Text PDFClinicopathological and molecular insights into odontogenic tumors associated with syndromes: A comprehensive review.
World J Exp Med
December 2024
Department of Diagnosis in Pathology and Oral Medicine, Faculty of Dentistry, Universidad de la República, Montevideo 1600, Uruguay.
The association between genetic syndromes and odontogenic tumors encompasses several entities, reflecting the intricate interplay between genetic factors and the development of these lesions. The present study aimed to comprehensively investigate the associations between genetic syndromes and odontogenic tumors. We delineated the diverse spectrum of syndromic connections, including key syndromes such as Gardner syndrome, Gorlin syndrome, Schimmelpenning syndrome, and others.
View Article and Find Full Text PDFExploring the Rarity: Clinical insights and histopathological diversity of hybrid desmoplastic-plexiform ameloblastoma.
Semin Diagn Pathol
December 2024
Department of Oral Pathology & Microbiology, King George's Medical, University, Lucknow 226003 UP, India. Electronic address:
Ameloblastoma represents a rare and locally aggressive odontogenic neoplasm, notable for its histopathological diversity. Among its subtypes, the desmoplastic and plexiform variants are relatively rare, with the hybrid form, encompassing both architectural patterns, representing an even more exceptional entity. This article delineates the clinical, radiological, and histopathological profile of a 45-year-old male presenting with pain persisting over the past month in the right posterior maxillary region.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!