Purpose: This review aims to summarize the evidence for the role of mechanotherapies and rehabilitation in supporting the synergy between regeneration and repair after an orthobiologic intervention.
Methods: A selective literature search was performed using Web of Science, OVID, and PubMed to review research articles that discuss the effects of combining mechanotherapy with various forms of regenerative medicine.
Results: Various mechanotherapies can encourage the healing process for patients at different stages. Taping, bracing, cold water immersion, and extracorporeal shockwave therapy can be used throughout the duration of acute inflammatory response. The regulation of angiogenesis can be sustained with blood flow restriction and resistance training, whereas heat therapy and tissue loading during exercise are recommended in the remodeling phase.
Conclusion: Combining mechanotherapy with various forms of regenerative medicine has shown promise for improving treatment outcomes. However, further studies that reveal a greater volume of evidence are needed to support clinical decisions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00264-021-05253-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Esthetic Twin Block Approach for Correction of Developing Class II Division 1 Malocclusion of an 11-year-old Female Patient: A Case Report.
Int J Clin Pediatr Dent
October 2024
Department of Pediatric and Preventive Dentistry, Bharati Vidyapeeth (Deemed to be University), Dental College and Hospital, Navi, Mumbai, Maharashtra, India.
Unlabelled: An 11-year-old female patient with developing class II division 1 malocclusion having retrognathic mandible and crowding in the lower arch, horizontal growth pattern, with convex profile, hyperactive mentalis muscle, positive visual treatment objective (VTO) in cervical vertebral maturation indicator (CVMI) stage 4 was planned to be treated using modification of conventional twin block appliance. Though a wide variety of myofunctional appliances like activator, Bionator, and Frankel appliances can be delivered to the patient, twin block appliance being a mechanofunctional appliance is routinely preferred by operators due to simplicity of its design and construction in comparison to other appliances. One of the biggest challenges in management of growing patients with skeletal class II malocclusion is the compliance of patients in wearing the myofunctional appliances.
View Article and Find Full Text PDFUnraveling the Role of the Tumor Extracellular Matrix to Inform Nanoparticle Design for Nanomedicine.
Adv Sci (Weinh)
December 2024
International Clinical Research Center, St. Anne's University Hospital, Brno, 60200, Czech Republic.
Article Synopsis
- The extracellular matrix (ECM) and its mechanobiology play a crucial role in tumor growth, making mechanotherapy a promising treatment for cancers by restoring ECM to a healthier state and aiding chemotherapy delivery.
- Manipulating the ECM, especially using nanoparticles (NPs), shows potential for innovative cancer treatments, although dense ECMs can hinder NP effectiveness.
- The review discusses the interaction between ECM and NPs, highlights recent advancements in mechanotherapy, and emphasizes the need for better understanding to enhance nanomedicine design for effective clinical applications.
Invited Review for 20th Anniversary Special Issue of PLRev "AI for Mechanomedicine".
Phys Life Rev
December 2024
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, China. Electronic address:
Mechanomedicine is an interdisciplinary field that combines different areas including biomechanics, mechanobiology, and clinical applications like mechanodiagnosis and mechanotherapy. The emergence of artificial intelligence (AI) has revolutionized mechanomedicine, providing advanced tools to analyze the complex interactions between mechanics and biology. This review explores how AI impacts mechanomedicine across four key aspects, i.
View Article and Find Full Text PDFSkeletal class III malocclusion is a therapeutic challenge in orthodontic practice. Reverse functional appliances such as reverse twin block (RTB) are used to correct class III skeletal and occlusal disharmonies associated with functional anterior shift in growing patients. However, treatment options become limited with increasing age, especially when patients desire nonsurgical and nonextraction camouflage treatment.
View Article and Find Full Text PDFA synergistic approach for modulating the tumor microenvironment to enhance nano-immunotherapy in sarcomas.
Neoplasia
May 2024
Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Cyprus. Electronic address:
The lack of properly perfused blood vessels within tumors can significantly hinder the distribution of drugs, leading to reduced treatment effectiveness and having a negative impact on the quality of life of patients with cancer. This problem is particularly pronounced in desmoplastic cancers, where interactions between cancer cells, stromal cells, and the fibrotic matrix lead to tumor stiffness and the compression of most blood vessels within the tumor. To address this issue, two mechanotherapy approaches-mechanotherapeutics and ultrasound sonopermeation-have been employed separately to treat vascular abnormalities in tumors and have reached clinical trials.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!